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Nicotine transdermal delivery system

A delivery system, nicotine technology, applied in nervous system diseases, sheet-like delivery, medical preparations of non-active ingredients, etc., can solve problems such as poor adhesion of percutaneous absorption preparations, highly complicated preparation methods, and reduced cohesion

Inactive Publication Date: 2006-12-27
NITTO DENKO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In such use of the nicotine transdermal delivery system, there is a problem in the nicotine transdermal delivery system using a conventional acrylic adhesive or a rubber adhesive as an adhesive in the adhesive layer to fix the formulation to the skin: Skin irritation during peeling preparation change
However, in order to obtain good skin adhesion, some cohesion needs to be sacrificed, when priority is given to adhesion, there is a problem that due to the reduction of cohesion, the adhesive flows out from the edge of the formulation during storage, thus, this causes cold Fluidity (low temperature fluidity)
However, the low-temperature coating according to this method cannot completely solve the problem of nicotine volatilization, and requires the operation of filling additional quantities to obtain the desired quantity of nicotine
Moreover, the preparation method is highly complicated due to the specific composition of the method, and the obtained percutaneous absorption preparation is slightly less sticky

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-5

[0096] Under a nitrogen atmosphere, polymerize 2-ethylhexyl acrylate (95 parts), acrylic acid (5 parts) at 60°C in a separable flask equipped with a reflux condenser, a stirrer, a thermometer and a dropping funnel and a nitrogen insertion tube , ethyl acetate (100 parts) and benzoyl peroxide (benzoyl peroxide) (0.2 part, BPO, manufactured by NOF Corporation, product name is Nyper BW) 15 hours, obtain binder solution (hereinafter referred to as binder Solution A). 49.93, 54.923, 59.916, 64.909, and 69.902 parts of the obtained binder solutions A were taken with respect to the binder solid content, and placed in reaction containers, respectively. Add respectively 50, 45, 40, 35 and 30 parts of isopropyl myristate relative to the solid content of the binder in each reaction vessel, and then add 0.07, 0.077, 0.084, 0.091 and 0.098 parts (0.14% of the binder) of Coronate HL (manufactured by Nippon Polyurethane Industry Co., Ltd.), and the mixture was thoroughly stirred. Each of t...

Embodiment 6-10

[0099] The nicotine transdermal delivery system of Examples 6-10 was obtained in the same manner as in Example 1, except that Coconad MT (manufactured by Kao Corporation, caprylic acid capric triglyceride) was used instead of isopropyl myristate, respectively Binder solution A at 49.93, 54.923, 59.916, 64.909, 69.902 parts relative to binder solids, and Coconad MT at 50, 45, 40, 35 and 30 parts relative to binder solids and 0.07 , 0.077, 0.084, 0.091 and 0.098 parts (0.14% binder) of Coronate HL (manufactured by Nippon Polyurethane Industry Co., Ltd.).

Embodiment 11-14

[0101] Get 79.68, 69.72, 59.76 and 49.80 parts of 2-ethylhexyl acrylate / vinyl acetate / 2-hydroxyethyl acrylate=78 / 16 / 6 (weight ratio, DURO-TAK2196, National Starch & Chemical Company), respectively placed in the reaction vessel. Add 20, 30, 40 and 50 parts of Coconad MT (manufactured by Kao Corporation, caprylic acid capric acid triglyceride) relative to the amount of binder solids in each reaction vessel, and the addition ratio is 0.32, 0.28, 0.24 and 0.20 parts (of 0.4% of the binder) of ALCH (manufactured by Kawaken Fine Chemicals Co., Ltd., ethylacetoacetate·aluminum diisopropoxide) as a binder, and the mixture was thoroughly stirred. Each of the resulting solutions was used to prepare crosslinked adhesive layers of Examples 11-14 described below.

[0102] The resulting solution was applied to the peel-treated surface of a polyester film release liner having a peel-treated surface on one side to a thickness of 80 μm after drying, and an adhesive layer was obtained after dr...

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Abstract

The present invention provides a nicotine transdermal delivery system including an adhesive layer containing a free base nicotine and a liquid ingredient compatible with the adhesive, wherein the adhesive layer is crosslinked, and the liquid ingredient is contained in a proportion of 20-75 parts by weight, per 100 parts by weight of the adhesive layer as a whole. The nicotine transdermal delivery system has good adhesiveness and cohesion, and simultaneously achieves low irritation to the skin during peeling off and a fine feeling during adhesion.

Description

[0001] invention technical field [0002] The present invention relates to a nicotine transdermal delivery system that adheres to the outer skin to allow percutaneous absorption of nicotine into the body. Background of the invention [0003] It is well known that nicotine contained in cigarettes is closely related to habitual smoking. As a method of reducing smoking, it has been proposed to suppress habitual smoking by administering a certain form of nicotine instead of smoking into the living body, and various methods of administering nicotine to cultivate anti-smoking emotions have been proposed globally. These methods are called nicotine replacement therapy and include the methods described below. [0004] One of them is the method of oral administration of nicotine contained in chewing gum or medicated lozenges to the human body. According to this method of administration, nicotine is absorbed from the mucous membranes into the oral cavity when the patient chews the gum ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/465A61K47/14A61K47/30A61P25/34
CPCA61K31/465A61K9/7061A61P25/26A61P25/34A61K9/70
Inventor 里田史朗黑田英利斋藤纯一二宫和久
Owner NITTO DENKO CORP