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Use of chloride 13-hexyl berberine and chloride 13-hexyl palmatine in preparation of medicine for treating vagina and oral cavity infection-inflammation

A technology for berberine and trichomonas vaginitis, which can be applied in the directions of anti-infective drugs, drug combinations, drug delivery, etc., and can solve problems such as unseen activities and uses.

Inactive Publication Date: 2007-03-07
CHUGOKU IGAKU KAGAKUIN HIFUBIYOU KENKYUSHO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, HP-13 has no reports on its activity and use on diseases such as fungal, trichomonal vaginitis and bacterial vaginosis, oral mucosal bacterial infectious diseases and recurrent oral ulcers

Method used

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  • Use of chloride 13-hexyl berberine and chloride 13-hexyl palmatine in preparation of medicine for treating vagina and oral cavity infection-inflammation
  • Use of chloride 13-hexyl berberine and chloride 13-hexyl palmatine in preparation of medicine for treating vagina and oral cavity infection-inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Preparation of suppository

[0020] Weigh 0.2-1g of HB-13 or HP-13, add suppository base to 100g, and prepare 50 suppositories according to conventional suppository operations, each with an effective drug content of 4mg-20mg.

[0021] Indications: Fungal, Trichomonas, Bacterial Vaginitis.

[0022] Usage: Put the suppository into the vagina

Embodiment 2

[0023] Example 2 Preparation of gel

[0024] Weighing:

[0025] HB-13 or HP-13 0.2~2g

[0026] Surfactant 0.5~1g

[0027] Propyl alcohol 10~20g

[0028] Carpopol 940 0.5~2g

[0029] Triethanolamine amount

[0030] Distilled water to 100g

[0031] According to the conventional method of gel preparation.

[0032] How to use: Apply an appropriate amount of this gel to the affected area.

Embodiment 3

[0033] Example 3 Preparation of cream

[0034] Weighing:

[0035] HB-13 or HP-13 0.5~2g, polyoxyethylene (40) stearate 2~5g

[0036] Cetyl alcohol 6~8g glycerol 5~10g

[0037] White Vaseline 8~10g absolute ethanol

[0038] Liquid paraffin 8~19g ethyl ester 0.1g

[0039] Monoglyceride 2~5g distilled water add to 100g

[0040] Make o / w cream according to the conventional operation of cream.

[0041] Indications: fungal, trichomonal vaginitis and bacterial vaginosis, bacterial infections of the oral mucosa, and recurrent oral ulcers.

[0042] How to use: Apply an appropriate amount of this cream to the affected area.

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PUM

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Abstract

The invention relates to a method for using alcaine 13-hexyl berberine and relative alcaine 13-hexyl palmatine to prepare the external drug that treats colpitis, etc. Wherein, 13-hexyl berberine and relative alcaine 13-hexyl palmatine can kill pus organism, Chlamydia, etc that causes trichomonal vaginitis and restrain pus organism that caused pus organism. And its emulsion and paste can treat the mucosa part, and it can be made into mucosa. The invention has antiphlogistic function to shorten treatment time.

Description

Technical field [0001] The present invention relates to the preparation of the compound 13-hexylberberine hydrochloride (HB-13 for short) and its congener 13-hexylpalmatine hydrochloride (HP-13 for short) for the treatment of skin and mucous membrane infectious vaginitis, vaginosis, and oral mucosa Application of topical drugs for infectious and inflammatory diseases. Background technique [0002] 13-hexylberberine hydrochloride (HB-13), molecular formula C 26 H 31 NO 4 ·HCl, molecular weight 457.98, has the following chemical structure: [0003] [0004] The above-mentioned HB-13 is composed of the parent compound berberine hydrochloride (abbreviated as Bo) molecule at position 13 -H by hexyl-C 6 H 13 The substituted derivative is obtained by reacting Bo in aqueous medium with dilute sodium borohydride lye to obtain dihydroberberine, and then reacting n-hexanal and dihydroberberine in acetic acid ethanol to produce crude HB-13. Then it is further refined. [0005] As we all kn...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61K9/02A61K9/00A61P15/02A61P31/10A61P31/04A61P33/02A61P1/02
Inventor 郑家润张崇璞李耐三李新宇唐美育高纪伟徐兰芳
Owner CHUGOKU IGAKU KAGAKUIN HIFUBIYOU KENKYUSHO
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