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Method for determining patient's brain ictus genetic susceptibility

A stroke and patient technology, applied in biochemical equipment and methods, microbial determination/examination, etc., can solve problems such as unclear function and signal transduction pathway, low tyrosine kinase activity, etc.

Inactive Publication Date: 2007-04-04
FUWAI HOSPITAL OF CARDIOVASCULAR DESEASE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

VEGFR-1 and VEGFR-2 are high-affinity receptors for VEGF, but the tyrosine kinase activity of VEGFR-1 is low, and its exact function and signaling pathway are still unclear

Method used

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  • Method for determining patient's brain ictus genetic susceptibility
  • Method for determining patient's brain ictus genetic susceptibility
  • Method for determining patient's brain ictus genetic susceptibility

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0085] 1. Selection of stroke patients and control population:

[0086] The research project "Molecular Mechanism of Hypertension Susceptible to Stroke" is a national key basic research project funded by the Ministry of Science and Technology (973 project, subject number G200056901), and has been approved by the ethics committee of the Ministry of Health and the ethics committee of each clinical center, and all participants The informed consent of the patient.

[0087] From November 2000 to November 2001, 7 clinical centers in China, Beijing, Tianjin, Wuhan Tongji, Wuhan Xiehe, Xi'an, Chongqing, Shandong Yanzhou participated in a large-scale case-control study, and 2,000 stroke patients were selected. Correspondingly, 2000 cases of controls were selected in the same area according to the principle of gender and age matching. Case inclusion criteria: According to the ninth revision of the International Classification of Disease (ninth revision), three subtypes of stroke patien...

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PUM

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Abstract

A method for determining cerebrovascular disease genetic infectivity, its substance, composition and reagent kit are disclosed. The method includes determining VEGFR-2 gene polymorphic site-604T / G and / or +1192C / T and / or +1719A / T genetic polymorphic style. It can be used for cerebral thrombosis, spatial cerebral infarction and cerebral hemorrhage.

Description

technical field [0001] The present invention relates to a method for determining a patient's genetic susceptibility to cerebrovascular diseases (especially strokes including cerebral thrombosis, lacunar infarction, and cerebral hemorrhage), substances, compositions, and kits for the method and its uses. Background technique [0002] The prevalence of cerebrovascular disease is severe and the harm is serious [0003] Stroke, also known as stroke or cerebrovascular accident, is a group of acute cerebrovascular diseases with sudden onset and common feature of focal neurological deficit. Stroke has a very high mortality rate and disability rate. In my country, stroke is the second leading cause of death after cancer. More than 1 million people die from stroke every year, which is 2-2% of the death toll from coronary heart disease. 3 times. The prevention and treatment of cerebral apoplexy has become an important topic in the health work, and it has attract...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68
Inventor 惠汝太张伟丽孙凯石毅汪一波杨晓敏
Owner FUWAI HOSPITAL OF CARDIOVASCULAR DESEASE CHINESE ACAD OF MEDICAL SCI
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