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In-vivo biological reactor and its application

A bioreactor and inner catheter technology, applied in the field of biomedical engineering, can solve the problems of limiting the clinical application of tissue engineering products, slowness, etc., and achieve the effect of expanding clinical application indications, promoting directional differentiation, and reducing the number of requirements

Inactive Publication Date: 2011-09-14
谭强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Slow revascularization greatly limits the clinical application of tissue engineering products

Method used

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  • In-vivo biological reactor and its application

Examples

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Effect test

Embodiment 1

[0025] Example 1: Tissue-engineered bone junction in vivo bioreactor:

[0026] The present invention further illustrates the technical solutions and effects of the present invention through the following examples, but the technical solutions and effects of the present invention are not limited thereto.

[0027] 1. Construct the in vivo bioreactor:

[0028] The large-capacity perfusion pump Deltec R300 & Micro 3100 from Deltec Company of the United States was selected as the input pump system in the extracorporeal power pump system.

[0029] The REDON clinical portable drainage system of American Tyko Company was selected as the output pump system in the extracorporeal power pump system.

[0030] The CliniCathR PolyFlowR single-lumen polyurethane catheter from Deltec Corporation of the United States was selected as the catheter system in the body. One end is embedded in the tissue-engineered bone substitute that has been implanted in the patient, and the other end is connecte...

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Abstract

An intrabody bioreactor for the tissue-engineered organ transplantation is composed of an external powder pump system and an internal catheter system. It can be used to pump the cell culturing liquid containing the self blood serum of organ receptor, seed cells and growth factors into the transplanted organ and promote its vascularization.

Description

technical field [0001] The invention belongs to the field of biomedical engineering, and in particular relates to an in vivo bioreactor and its application. The in vivo bioreactor (IN-VIVO BIOREACTOR) of the present invention can maintain early nutrition and promote revascularization of tissue engineered tissue and organ substitutes implanted in vivo. Background technique [0002] Tissue engineering is an emerging biomedical high-tech discipline. Its basic definition is to promote the self-repair of damaged tissues and organs through the implantation of cells, scaffold materials and (or) various bioactive factors. (Tissue engineering is the persuasion of the body to heal itself, through the delivery to the appropriate sites, of molecular signals, cells and supporting structures.) The classic tissue engineering treatment process includes the following steps: 1) from the patient's own or allogeneic Allogeneic donors obtain all kinds of seed cells in vivo, and in vitro subcult...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/02A61F2/04A61F5/00A61M1/00A61M31/00A61B17/00
Inventor 谭强
Owner 谭强
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