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Hypoglycemic medicine preparation and its prepn. method

A pharmaceutical preparation and hypoglycemic technology, applied in the field of medicine, can solve the problems of irrationality, decreased insulin sensitivity, increased blood viscosity, etc.

Active Publication Date: 2007-04-18
河北百消丹药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Taking my country as an example, it has increased from 0.5% in the past to about 3% now. With the improvement of people's living standards in our country, people's diet structure has undergone great changes. Long-term unreasonable diet makes the long-term secretion of insulin in the body relatively low. more, gradually lead to decreased sensitivity of insulin target cells to insulin, resulting in hyperglycemia, and the incidence of diabetes also increases. At present, most drugs for treating diabetes focus on stimulating islets to produce insulin. The sensitivity of the blood sugar has not been fundamentally improved, so once the drug is stopped for a period of time, the blood sugar often rebounds again. At the same time, due to the stimulation of the islets by the long-term medication, the islets are in a long-term tense working state, which eventually leads to exhaustion of the islet function. As a result, diabetics finally have to use extracorporeal insulin to help lower blood sugar, which will further lead to partial or complete loss of islet function. Heart, brain, kidney, skin and nerve complications may occur

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] (1) Ginseng leaves 3.2kg, astragalus 3.2kg, kudzu root 3.2kg, salvia miltiorrhiza 3.2kg, anemarrhena 1.5kg, mulberry leaves 1.5kg, chromium picolinate 0.55×10 -3 kg, selenium-enriched yeast 5.5×10 -3 kg, wherein chromium picolinate contains 12.5% ​​chromium, and selenium-enriched yeast contains 0.25% selenium;

[0051] (2) Take ginseng leaves, astragalus, anemarrhena, and mulberry leaves, add water to decoct twice, add 9 times the amount of water for the first time, cook for 1 hour, add 7 times the amount of water for the second time, and cook for 1 hour hours, combined the decoction, filtered, and the filtrate was concentrated to a clear paste with a thermal relative density of 1.28-1.32 at 60°C;

[0052] (3) Take Pueraria root and Salvia miltiorrhiza and decoct twice with water, add 9 times of water for the first time, boil for 1 hour, add 6-10 times of water for the second time, boil for 0.8 hour, combine the decoction, Filter, concentrate under reduced pressure un...

Embodiment 2

[0055] (1) Ginseng leaves 3.8kg, astragalus 3.8kg, kudzu root 3.8kg, salvia miltiorrhiza 3.8kg, anemarrhena 1.89kg, mulberry leaves 1.89kg, chromium picolinate 0.59×10 -3 kg, selenium-enriched yeast 5.9×10 -3 kg, wherein chromium picolinate contains 12.2% chromium, and selenium-enriched yeast contains 0.23% selenium;

[0056] (2) Take the four herbs of ginseng leaves, astragalus, anemarrhena, and mulberry leaves, add water to decoct twice, add 11 times the amount of water for the first time, and cook for 1.8 hours, add 9 times the amount of water for the second time, and cook for 1.4 hours hours, combined the decoction, filtered, and the filtrate was concentrated to a clear paste with a thermal relative density of 1.28-1.32 at 60°C;

[0057] (3) Take Pueraria root and Salvia miltiorrhiza and add water to decoct twice, add 11 times of water for the first time, boil for 1.8 hours, add 9 times of water for the second time, boil for 1.4 hours, combine the decoction, filter , con...

Embodiment 3

[0060] (1) Ginseng leaves 33.3kg, astragalus 33.3kg, kudzu root 33.3kg, salvia miltiorrhiza 33.3kg, anemarrhena 16.7kg, mulberry leaves 16.7kg, chromium picolinate 5.41×10 -3 kg, selenium-enriched yeast 58.6×10 -3 kg, of which 12.32% of chromium is contained in chromium picolinate, and 0.2277% of selenium is contained in selenium-enriched yeast.

[0061] (2) Take the four herbs of ginseng leaves, astragalus, anemarrhena, and mulberry leaves, add water to decoct twice, add 10 times the amount of water for the first time, and cook for 1.5 hours, add 8 times the amount of water for the second time, and cook for 1 hour hours, combined the decoction, filtered, and the filtrate was concentrated to a clear paste with a thermal relative density of 1.28-1.32 at 60°C;

[0062] (3) Add Pueraria root and Salvia miltiorrhiza to decoction twice, add 10 times the amount of water for the first time, boil for 1.5 hours, add 8 times the amount of water for the second time, boil for 1 hour, com...

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Abstract

A hypoglycemic medicine in the form of particles is prepared from chromium pyridylfomate, Se-enriched yeast, the extracts of 6 Chinese-medicinal materials including ginseng leaf, astragalus root, pueraria root, red sage root, etc. Its preparing process is also disclosed.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical preparation with anti-glycemic properties and a preparation method thereof. Background technique [0002] Diabetes is a systemic chronic progressive disease. Because the islet cells cannot secrete insulin normally, the relative or absolute deficiency of insulin and the decrease of target cells’ sensitivity to insulin lead to the disorder of sugar, protein, fat, water and electrolyte metabolism, so that liver glycogen and muscle glycogen cannot be synthesized. The clinical manifestations are elevated blood sugar, positive urine sugar and impaired glucose tolerance. The typical symptoms are "three more and one less", that is, polydipsia, polyuria, polyphagia, and weight loss; over time, it is accompanied by a series of complications; traditional Chinese medicine called diabetes Diabetes, the classic Chinese medical book - "Huangdi Neijing" is called "...

Claims

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Application Information

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IPC IPC(8): A61K36/8964A61K9/16A61P3/10A61K31/44
Inventor 易小平
Owner 河北百消丹药业有限公司
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