Supercharge Your Innovation With Domain-Expert AI Agents!

Method for obtaining graded pore structure in scaffolds for tissues and bone, and scaffolds with graded pore structure for tissue and bone

A technology of tissue regeneration and gradient change, applied in the field of obtaining gradient pore structures in scaffolds for tissues and bones and scaffolds for tissues and bones with gradient pore structures, which can solve problems such as interconnection limitations

Inactive Publication Date: 2007-05-02
AGENCY FOR SCI TECH & RES +1
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Methods such as salt washing and phase separation are limited in creating the necessary pore interconnectivity

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for obtaining graded pore structure in scaffolds for tissues and bone, and scaffolds with graded pore structure for tissue and bone
  • Method for obtaining graded pore structure in scaffolds for tissues and bone, and scaffolds with graded pore structure for tissue and bone
  • Method for obtaining graded pore structure in scaffolds for tissues and bone, and scaffolds with graded pore structure for tissue and bone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0042] To allow the scaffold 10 to closely mimic tissue, and to enhance the quality of tissue regeneration / bone growth within the implant, the scaffold 10 has gradient properties, including graded porosity. This helps to obtain optimal growth of different tissues and cells, increasing the ability of the implant to withstand varying mechanical loads at specific areas of the implant. The gradient structure of wells 12 facilitates the delivery of growth reagents in a controlled manner. It will thus assist in having controlled and directed osteogenesis and vascularization. Polymer mixtures of different polymers are used with different degradation rates, preferably corresponding to tissue, bone and blood vessel formation. This gives the scaffold enough support and strength to assist the regenerative process.

[0043] Pores 12 are graded such that core 14 of scaffold 10 provides the necessary support and delay for tissue growth as growth is initiated on the surface, allowing vascu...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a scaffold for at least one of: tissue regeneration and bone growth, the scaffold being fabricated from at least two polymers, the polymers being of differing rates of bio degradability. A first of the at least two polymers is able to be leached by a solvent, and all other polymers of the at least two polymers being either inert to the solvent or having a lower dissolution rate in the solvent. The scaffold has a graded porosity with high porosity at a surface of the scaffold, and low porosity at a core of the scaffold.

Description

technical field [0001] The present invention relates to a method for obtaining a graded pore structure in a scaffold for tissue and bone, and to a scaffold for tissue and bone with a graded pore structure. In particular (but not exclusively), the gradient pore structure provides initial structural strength and allows tissue growth under controlled degradation conditions. Background of the invention [0002] Tissue engineering techniques often require the use of temporary scaffolds as 3D templates for initial cell attachment and subsequent tissue formation. The ability of the scaffold to be metabolized by the body allows it to be gradually replaced by new cells to form functional tissue. [0003] Many traditional techniques such as fiber bonding, solvent casting, and particulate leaching have been developed to design and fabricate scaffolds. Using computer-controlled technology, rapid prototyping (prototyping) technology has also been able to design and manufacture stents. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/58A61L27/48A61L27/56
CPCA61L27/58A61L27/56A61L27/48C08J9/26B29C67/20A61L27/14
Inventor 查卓瑟卡兰·马格姆张苏霞郑美燕
Owner AGENCY FOR SCI TECH & RES
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com