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Novel extract of red sage root and dalbergia wood and preparation process thereof

An extract and the technology of Danshen, which are applied in the field of pharmaceutical composition and its preparation from Danshen Jiangxiang, can solve the problems of energy waste, low utilization rate, and many adverse reactions, and achieve controllable process, excellent drug effect, good reproducibility

Inactive Publication Date: 2007-05-30
陈文展
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The original process of salvia miltiorrhiza and daffodils are processed separately, resulting in waste of energy, and the volatile oil components of daffodils are directly used as medicine to make injections, which obviously has a low utilization rate and many adverse reactions
Solving these technical problems existing in the prior art is not something ordinary technicians can achieve without creative work, and it is not obvious

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: the preparation of salvia miltiorrhiza extract

[0019] Take 1000g of Salvia miltiorrhiza and 100g of Dalbergia basilica, add 10 times the amount of water, and distill to obtain a saturated water distillate. The distillate is added with 1000g of hydroxypropyl-β-cyclodextrin for inclusion, and the distillate is continuously added with hydroxypropyl-β-cyclodextrin under ultrasonic conditions. In β-cyclodextrin solution, sonicate for 8 hours, concentrate and dry to obtain the inclusion part of volatile oil;

[0020] After distilling the saturated water distillate, extract the remaining medicinal residues with water three times, 10 times the amount of water each time, 2 hours each time, add 95% ethanol to 75% concentration alcohol precipitation overnight after the water extract is concentrated, filter, continue to recover the ethanol from the filtrate, and concentrate After adding water to the solution and fully stirring, let it stand overnight, filter, contin...

Embodiment 2

[0023] Embodiment 2: the preparation of salvia miltiorrhiza extract

[0024] Take 100g of Salvia miltiorrhiza and 1000g of radix basilica, add 10 times the amount of water, and distill to obtain a saturated water distillate. The distillate is added with 1000g of β-cyclodextrin for inclusion, and the distillate is continuously added to the β-cyclodextrin solution under ultrasonic conditions. 12 hours, concentrated and then dried to obtain the inclusion part of the volatile oil;

[0025] After distilling the saturated water distillate, extract the remaining medicinal residues with water three times, each time with 15 times the amount of water, and each time for 2 hours. After the water extract is concentrated and fully stirred, add 95% ethanol to 70% alcohol precipitation overnight, filter, and continue the filtrate Recover ethanol, add water to the concentrated solution and let it stand overnight after fully stirring, filter, continue the pretreated ME-2 macroporous adsorption ...

Embodiment 3

[0028] Embodiment 3: the preparation of salvia miltiorrhiza extract

[0029] Combine 640g of Salvia Miltiorrhiza and 400g of Dalbergia, add 15 times the amount of water, and distill to obtain a saturated water distillate. Add 1000g of β-cyclodextrin to the distillate for inclusion, and continuously add β-cyclodextrin to the distillate while stirring with a high-speed emulsification cutting machine solution, stirred for 12 hours, concentrated and then dried to obtain the inclusion part of the volatile oil;

[0030] After distilling the saturated water distillate, extract the remaining medicinal residues with water three times, each time with 15 times the amount of water. After the water extract is concentrated, add 95% ethanol to 75% concentration for alcohol precipitation overnight, filter, continue to recover the ethanol from the filtrate, and add water to the concentrated solution to fully After stirring, let it stand overnight, filter, continue to put the filtrate on the pr...

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PUM

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Abstract

Disclosed is a red sage root and dalbergia wood extract, which is prepared from cyclodextrin inclusion compound of water saturation distillate of red sage root and dalbergia wood, and the water-soluble portions of red sage root and dalbergia wood. The extract can be used for preparing injections of various combinations of the raw materials with controllable process, stabilized quality, better repeatability, and improved effect.

Description

Technical field: [0001] The invention belongs to the field of traditional Chinese medicine injections, and relates to a new medicinal composition derived from salvia miltiorrhiza and a preparation method thereof. Background technique: [0002] Salvia miltiorrhiza, also known as red ginseng and purple miltiorrhiza, is the root of the perennial herb Salvia miltiorrhiza in the family Lamiaceae. Salvia Miltiorrhiza is bitter in nature and flavor, slightly cold, Guixin and Liver Channel. It has the effects of promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, nourishing blood and calming the nerves. Its active ingredients, water-soluble phenolic acids, have strong effects of expanding coronary vessels, lowering blood lipids, lowering blood viscosity, and anti-platelet aggregation. It can treat both the symptoms and the root causes of ischemic heart disease. [0003] Jiangxiang (English) Rosewood, alias: Jiangzhenxiang, Zijiangxiang, Hu...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61P9/10
Inventor 陈文展
Owner 陈文展
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