Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method of determining volume dependent hypertension via reduction in phosphorylation

a volume dependent hypertension and phosphorylation technology, applied in the field of volume dependent hypertension via phosphorylation reduction, can solve the problems of hypertension, elevated blood pressure or hypertension, and lack of accurate reliable means of detecting the presence of volume dependent hypertension involving higher arterial blood pressur

Inactive Publication Date: 2001-11-22
THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0012] It is further an object of the present invention to provide apparatus which facilitates such a determination and may employ a patient body specimen, such as blood serum or blood plasma.
[0014] It is a further object of the present invention to provide such a system which is reliable and will effectively distinguish chronic volume expansion hypertension from acute volume expansion hypertension, vasoconstriction hypertension and other types of hypertension.
[0015] It is another object of the present invention to provide such a method and related apparatus which is economical and may be practiced by paraprofessional personnel in an accurate manner.

Problems solved by technology

Elevated blood pressure or hypertension has long been recognized as a health problem.
Despite known means of measuring blood pressure of a patient as by a sphygmomanometer, for example, there is lacking an accurate reliable means of detecting the presence of volume dependent hypertension involving higher arterial blood pressure by use of a body specimen, such as blood serum or blood plasma.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method of determining volume dependent hypertension via reduction in phosphorylation
  • Method of determining volume dependent hypertension via reduction in phosphorylation
  • Method of determining volume dependent hypertension via reduction in phosphorylation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0031] In order to confirm the reliability of substantial reduction in phosphorylation of the blood-derived protein (Mr=72,000), experiments were performed on rats selecting two models of experimental hypertension which exemplify the two major modes of chronic essential hypertension (high blood pressure).

[0032] In the first model, the effects of chronic volume expansion employing DOCA-salt hypertension as discussed in Schenk, The Pathogenesis of DOCA-salt Hypertension, J. Pharmacol. Toxicol Methods, 27:pp. 161-170 (1992) was involved. The second model related to chronic vasoconstriction. The two-kidney, one clip (2K1C) model was prepared in accordance with the procedure of Huang, et al. Bilateral Renal Function Responses to Converting Enzyme Inhibitor (SQ 20, 881) in two-kidney, one clip Goldblatt Hypertensive Rats, Hypertension, 3:pp. 285-293 (1981). The experiments in connection with both types of hypertension were conducted with a view toward determining the effect of these types...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
pHaaaaaaaaaa
pHaaaaaaaaaa
pHaaaaaaaaaa
Login to View More

Abstract

A method of determining the presence of chronic volume dependent hypertension is provided-wherein a determination is made as to whether there has been a substantial reduction in phosphorylation of the blood-derived protein or renal proximal brush border membrane protein and if such reduction exists concluding that chronic volume dependent hypertension exists in a patient. The method may advantageously be practiced by employing blood serum or blood plasma as the body specimen containing the protein in determining whether a patient has chronic volume dependent hypertension, a cellular component of the blood, such as a blood-derived protein coming from the plasma membrane of lymphocytes. The method may include subsequent therapeutic patient treatment. Related diagnostic apparatus is also provided.

Description

[0001] 1. Field of the Invention[0002] The present invention provides a means for determining whether a patient has volume dependent hypertension and, more specifically, it provides such a method based upon determining if a substantial reduction in phosphorylation of a specific protein exists. The invention also relates to a diagnostic apparatus employable in making such determination.[0003] 2. Description of the Prior Art[0004] Elevated blood pressure or hypertension has long been recognized as a health problem. It is a very common disease which can have widespread effects on a patient's body and frequently, unlike numerous other diseases, is asymptomatic.[0005] Despite known means of measuring blood pressure of a patient as by a sphygmomanometer, for example, there is lacking an accurate reliable means of detecting the presence of volume dependent hypertension involving higher arterial blood pressure by use of a body specimen, such as blood serum or blood plasma.[0006] From a path...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(United States)
IPC IPC(8): G01N33/53G01N33/68
CPCG01N33/6893G01N2333/9121Y10T436/105831Y10T436/106664G01N2800/321
Inventor PUSCHETT, JULES B.
Owner THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com