FHIT proteins and nucleic acids and methods based thereon
a technology applied in the field of fhit proteins and nucleic acids and methods based thereon, can solve the problems of hampered isolation of involved gene(s), substantial death and health costs in society, and the overall survival rate has not improved significantly, so as to reduce the expression level or activity of fhit proteins, the effect of reducing the expression level or activity
Inactive Publication Date: 2004-12-30
THOMAS JEFFERSON UNIV
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Problems solved by technology
Cancer remains one of the most severe health problems in America, accounting for substantial fatality and health costs in society.
Deletions may cause loss of tumor suppressor genes, leading to malignancy.
However, the observation that allelic losses often involve most of the 3p has hampered the isolation of the involved gene(s).
Lung cancer is a major cause of mortality worldwide and the overall survival rate has not improved significantly in the last 20 years.
Despite the success achieved by primary prevention, lung cancer is still an overwhelming medical and social problem.
Method used
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[0045] The present invention relates to nucleotide sequences of PHIT genes and amino acid sequences of their encoded Fhit proteins, as well as derivatives and analogs thereof, and antibodies thereto.
[0046] As described by way of example infra, the present inventors have isolated and characterized a human FHIT gene, that is involved in esophageal, gastric, colon, kidney, and other cancers. Mutations in FHIT gene sequences leading to loss of FHIT gene function are associated with cancer.
[0047] The present invention further relates to the use of FHIT genes and related nucleic acids and their encoded-proteins or derivatives or analogs thereof, and antibodies thereto, in assays for the detection and in treatment / prevention of disease states associated with chromosomal or molecular abnormalities and / or increased expression of FHIT, such as cancer. The present invention also relates to therapeutic compositions comprising Fhit proteins, derivatives or analogs thereof, antibodies thereto, nu...
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The present invention relates to nucleotide sequences of FHIT genes and amino acid sequences of their encoded proteins, as well as derivatives and analogs thereof, and antibodies thereto. The FHIT gene sequence is mutated in diseases involving cell overproliferation, particularly malignancies of the digestive tract. The present invention further relates to the use of FHIT genes and their encoded proteins as diagnostic and therapeutic reagents for the detection and treatment of disease states associated with cell overproliferation.
Description
[0001] This is a continuation of U.S. patent application Ser. No. 09 / 717,054, filed Nov. 21, 2000, which is a continuation of U.S. patent application Ser. No. 08 / 605,430, filed Feb. 22, 1996, which issued as U.S. Pat. No. 6,242,212 on Jun. 5, 2001, which is a continuation-in-part of U.S. patent application Ser. No. 08 / 598,873, filed Feb. 9, 1996, which issued as U.S. Pat. No. 5,928,884 on Jul. 27, 1999, the entire disclosure of which is incorporated herein by reference.1. INTRODUCTION[0003] The present invention relates to nucleotide sequences of the tumor suppressor FHIT genes and amino acid sequences of their encoded proteins, as well as derivatives and analogs thereof and antibodies thereto. The present invention relates to the use of nucleotide sequences of FHIT genes and amino acid sequences of their encoded proteins, as well as derivatives and analogs thereof and antibodies thereto, as diagnostic and therapeutic reagents for the detection and treatment of cancer. The present i...
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IPC IPC(8): A61K31/00A61K31/70C12N15/02A61K31/7088A61K38/00A61K48/00A61P1/00A61P11/00A61P13/00A61P13/12A61P15/00A61P19/00A61P35/00C07K14/47C07K16/18C07K19/00C12N1/21C12N5/10C12N15/00C12N15/01C12N15/09C12N15/12C12P21/02C12P21/08C12Q1/68
CPCA61K38/00C07K14/4703C07K16/18C07K2319/00A61P1/00A61P11/00A61P13/00A61P13/12A61P15/00A61P19/00A61P35/00
Inventor CROCE, CARLO M.HUEBNER, FRANCES KAY
Owner THOMAS JEFFERSON UNIV