Method of preparing an immunologically inert graft material from body tissue and material made with the method

a technology of immunological inert grafts and body tissue, which is applied in the field of biocompatible graft materials and can solve the problems of incomplete rejection of the graft material itself, high cost, and complex methods, and achieve the effect of conserving the body tissu

a technology of immunological inert grafts and body tissue, which is applied in the field of biocompatible graft materials and can solve the problems of incomplete rejection of the graft material itself, high cost, and complex methods, and achieve the effect of conserving the body tissu

US20050238688A1Inactive Publication Date: 2005-10-27BRENNEN MEDICAL
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  • Method of preparing an immunologically inert graft material from body tissue and material made with the method

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Embodiment Construction

[0016] Although the disclosure hereof is detailed and exact to enable those skilled in the art to practice the invention, the physical embodiments herein disclosed merely exemplify the invention which may be embodied in other specific structure. While the preferred embodiment has been described, the details may be changed without departing from the invention, which is defined by the claims.

[0017] As indicated above, graft materials produced by the method of the present invention may be used for surgical procedures such as slings for treatment for urinary incontinence, surgical meshes for repair of hernias, bulking agents for cosmetic or reconstructive surgery, abdominal wall reconstructions, pelvic floor reconstructions, heart valve replacements, pericardium repairs, or arterial transplants.

[0018] While the method of the present invention may be utilized to produce immunilogical inert graft material from tissues such as the arteries, heart valves, bone, or other organs and tissues...

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Abstract

A method of preparing an immunologically inert graft material from body tissue is described. Body tissue having cellular material disposed within an extracellular matrix is lysed by alternatingly exposing the body tissue to a hypertonic solution and a hypotonic solution to create an osmotic pressure gradient across the cellular material. Antigens present in the body tissue are deactivated by exposing the body tissue to a bleach solution, sodium hydroxide, or an iodophor solution. The body tissue is stabilized by soaking the body tissue in an isotonic solution. In addition, an immunologically inert collagenic graft material produced by a method is disclosed.

Description

RELATED APPLICATIONS [0001] This application is a Divisional Application of U.S. application Ser. No. 10 / 086,933, filed Mar. 1, 2002, entitled ā€œBiocompatible Tissue for Therapeutic Use & Method of Making Sameā€ now issued as ______ which is a Continuation of U.S. application Ser. No. 09 / 814,339, filed Mar. 21, 2001 entitled ā€œBiocompatible Tissue for Therapeutic Use & Method of Making Sameā€ and now abandoned.FIELD OF THE INVENTION [0002] The present invention relates to a biocompatible graft material and a method for making the same. More specifically, the method of the present invention produces a substantially immunologically inert, non-toxic, non-allergenic, non-irritating, non-mutigenic, and non-hemolytic extra cellular matrix suitable for use as a graft material. BACKGROUND OF THE INVENTION [0003] In treating many illnesses and injuries, it is often useful to replace damaged or injured tissues with a biocompatible graft material. Examples of such graft materials are diverse and i...

Claims

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Application Information

Patent Timeline
27 Oct 2005
Publication
US20050238688A1
IPC
A61K35/12; A61L2/00; A61L27/36; A61L27/38
CPC
A61K35/12; A61L2/0088; A61L27/38; A61L27/3683; A61L27/3687; A61L27/3633
Inventors
KLEIN, DEAN; KATZNER, LEO D.