Human antibodies derived from immunized xenomice

a technology of human antibodies and xenomice, which is applied in the field of immunology, can solve problems such as problems in the use of human antibodies in vivo diagnostics, in particular, and in the treatment of human diseases
US20060040363A1Inactive Publication Date: 2006-02-23KUCHERLAPATI RAJU +4
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
KUCHERLAPATI RAJU
Publication Date
2006-02-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

Antibodies with fully human variable regions against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. Various subsequent manipulations can be performed to obtain either antibodies per se or analogs thereof.
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Description

TECHNICAL FIELD

[0001] The invention relates to the field of immunology, and in particular to the production of antibodies. More specifically, it concerns producing such antibodies by a process which includes the step of immunizing a transgenic animal with an antigen to which antibodies are desired. The transgenic animal has been modified so as to produce human, as opposed to endogenous antibodies. BACKGROUND ART

[0002] PCT application WO 94 / 02602, published 3 Feb. 1994 and incorporated herein by reference, describes in detail the production of transgenic nonhuman animals which are modified so as to produce antibodies with fully human variable regions rather than endogenous antibodies in response to antigenic challenge. Briefly, the endogenous loci encoding the light and heavy immunoglobulin chains are incapacitated in the transgenic hosts and loci encoding human heavy and light chain proteins are inserted into the genome. In general, the animal which provides all the desired modifi...

Claims

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