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Method for treating hyperlipidemia

a hyperlipidemia and hyperlipidemia technology, applied in the field of hyperlipidemia treatment, can solve the problems of inability to fully reduce the blood cholesterol level of patients, unadvisable treatment with an increased dose of hmg-coa reductase inhibitors, etc., and achieve excellent effect in lowering blood cholesterol levels

Inactive Publication Date: 2006-03-02
KOWA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0008] An object of the present invention is to provide a method for treating hyperlipidemia and hypercholesterolemia, which has an excellent blood cholesterol lowering action.
[0012] The methods for treating hyperlipidemia and hypercholesterolemia according to the present invention are effective for the treatment of hyperlipidemia and hypercholesterolemia in that these exhibit excellent action in lowering blood cholesterol level.

Problems solved by technology

Many patients suffering from hyperlipidemia have a higher blood cholesterol level and their blood cholesterol level is not always possible to fully be lowered by the administration of an HMG-CoA reductase inhibitor.
In such a case, treatment with an increased dose of an HMG-CoA reductase inhibitor is not advisable from the viewpoint of safety.

Method used

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  • Method for treating hyperlipidemia

Examples

Experimental program
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Effect test

example 1

Blood cholesterol Level Lowering Effect Brought About by the Concomitant use of pitavastatin calcium Salt and ezetimibe

[0025] The blood cholesterol level lowering effect when a calcium salt of pitavastatin and ezetimibe were coadministered was measured by the below-described testing method. For comparison, a calcium salt of atorvastatin was used instead of the calcium salt of pitavastatin and the effect brought about by the concomitant use of two medicaments was measured in a similar manner.

1. Animals Provided for the Test and their Breeding Environment

[0026] Six-week-old Hartley male guinea pigs (purchased from Nippon SLC) were provided for the test. Throughout the test period, they were bred in a breeding room maintained at a light-dark cycle (a light term by a room light: from 7:00 am to 7:00 pm), a temperature of 23±3° C. and a humidity of 55±15% and fed with a solid feedstuff (“RC-4”, product of Oriental Yeast Industry) and tap water ad libitum.

2. Preparation of Medicamen...

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PUM

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Abstract

Provided is a method for treating hyperlipidemia or hypercholesterolemia, which comprises administering effective doses of ezetimibe and pitavastatin or a salt or lactone derivative thereof.

Description

TECHNICAL FIELD [0001] The present invention relates to a method for treating hyperlipidemia, which exhibits an excellent blood cholesterol-lowering action. BACKGROUND ART [0002] Hyperlipidemia is a symptom characterized by the abnormal elevation of lipoprotein levels in blood, particularly cholesterol levels in blood. Hyperlipidemia is known to be closely linked to diseases such as arteriosclerosis and myocardial infarction and its treatment is considered extremely important. [0003] There are a variety of drugs available for the treatment hyperlipidemia or hypercholesterolemia. At present, HMG-CoA reductase inhibitors such as lovastatin, simvastatin, pravastatin, fluvastatin, atorvastatin, rosuvastatin and pitavastatin are most commonly used for its treatment. Of these, pitavastatin ((3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoic acid) is known to exhibit a potent HMG-CoA reductase inhibitory action and therefore be useful as an antihyperlipide...

Claims

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Application Information

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IPC IPC(8): A61K31/47A61K31/366A61K31/225
CPCA61K31/397A61K31/47A61K31/4709A61K2300/00A61P3/06A61P43/00A61P9/10
Inventor AOKI, TAROYAMAZAKI, HIROYUKIMAEJIMA, TAKASHI
Owner KOWA CO LTD
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