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Treatment of cancer and compositions

a cancer and composition technology, applied in the field of cancer diagnosis, prognosis and treatment, can solve the problem of insufficient treatment of metastatic melanoma

Inactive Publication Date: 2006-06-22
JOHN WAYNE CANCER INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0005] One object of the invention is to provide genetic markers and methods for diagnosis, prognosis, and treatment of cancer. Another object of the invention is to provide compositions for preventing and treating diseases.

Problems solved by technology

[4] There is no adequately proven treatment for metastatic melanoma.

Method used

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  • Treatment of cancer and compositions
  • Treatment of cancer and compositions

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Material and Methods

Experimental Design

[0075] This study utilized primary melanomas and / or sentinel LN (SLN) metastases from 12 AJCC clinical stage I / II (no palpable LN metastasis) melanoma patients and 2 matching pairs of cell lines derived from primary melanoma and LN metastasis from 2 different patients. The samples were divided into 4 groups as shown in Table 1. The study was divided into 2 stages. The first stage compared gene-expression differences between Group 1 and Group 2 by using a 96-gene cDNA microarray that is functionally-focused to metastasis-associated genes. After the differentially regulated genes were identified, as a partially validative procedure, the second stage analyzed the trend in expression levels of these genes as melanoma progressed from stage I / II primary melanoma (Group 1), to stage III primary melanoma (Group 3), to LN metastasis (Group 4).

TABLE 1Group 1Primary melanomas from stage I / II patients -No SLN metastasis (n = 5)Group 2Primary melanoma...

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Abstract

The invention discloses a method of identifying a gene associated with stage III primary cancer or lymph node metastasis. The genes so identified include CAV1, CST3, LIMK1, MMP2, MMP15, VEGF, ETV4, MMP9, PIK3C2B, and SERPIN1. Also disclosed are methods for diagnosis, prognosis, and treatment of cancer. The invention further discloses compositions for preventing and treating diseases.

Description

RELATED APPLICATION [0001] The present application claims priority to U.S. Provisional Application Ser. No. 60 / 618,409 filed on Oct. 12, 2004, the content of which is incorporated herein by reference.FIELD OF THE INVENTION [0002] The present invention relates generally to cancer diagnosis, prognosis, and treatment. In particular, the invention relates to detection of genetic markers indicative of cancer such as melanoma, breast cancer, colon cancer, lung cancer, and merkel cell carcinoma in biological samples. The invention also relates to compositions for preventing and treating diseases, e.g., by administering the compositions topically to a subject. BACKGROUND OF THE INVENTION [0003] Both incidence and mortality from melanoma continue to rise in the United States. In 1992, the projected annual incidence and mortality from melanoma were 32,000 and 6,700, respectively.[1] By 2004, these figures had increased to 55,100 and 7,910, respectively.[2] The lifetime risk of developing mela...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12Q1/68
CPCC07K14/4748C12Q1/6886C12Q2600/106C12Q2600/112C12Q2600/118C12Q2600/136C12Q2600/158A61P35/00
Inventor ESSNER, RICHARD
Owner JOHN WAYNE CANCER INST
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