Cytochrome P450 enzyme complexes and methods of treatment using the same
a technology of cytochrome p450 and enzyme complex, which is applied in the field of living organism treatment methods and compositions, can solve the problems of population that is left without the ability to defend adequately against xenobiotics, unavoidable p450 inhibitors, etc., and achieve the effect of increasing the amount of p450:fmn enzyme complexes and improving nutrition
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example i
[0062] First Exemplary Composition: FMN
Concentration per doseCompositionBroad RangeNarrow RangeFMN0.01-50mg3-5mgCod liver oil1-2500mg100-1000mg
[0063] Second Exemplary Composition: Drink
Concentration per 100 ml doseCompositionBroad RangeNarrow RangeXylose0.1-1%1-1000 gFMN1-1000 ppm1 mcg-5 mg
[0064] Third Exemplary Composition
ConcentrationCompositionBroad RangeNarrow RangeFMN0.01-20mg1-5mgAnalgesics1-2000mg5-100mg
[0065] Fourth Exemplary Composition
ConcentrationCompositionBroad RangeNarrow RangeFMN 1-5 mg 2-5 mgNADP10-100 mg10-50 mgBicarbonateexcipientexcipient
[0066] Fifth Exemplary Composition
ComponentDoseRangeFMN5 mg1-5 mgLiver extract1 mg10 mcg-2 g
[0067] Sixth Exemplary Composition: Drink
ConcentrationCompositionBroad RangeNarrow RangeFMN1 mcg-50 mg10 mcg-5 mgD-Xylose1-1000 g5-50gEtOHexcipientexcipientCarbon dioxideexcipientexcipientWaterexcipientexcipient
[0068] Seventh Exemplary Composition: Natural Sweetener Suitable for People with Diabetes
ConcentrationCompositionBro...
example 2
[0070] The following example illustrates an application of human P450 compositions according to the present invention. Procedures followed previously described methods, e.g., U.S. Pat. No. 6,020,288; M. Markwell, et al., Methods of Enzymology 72: 296-303 (1981); C. A. Mihaliak, et al., Methods in plant biochemistry 19: 261-279 (1993); R. Donaldson, et al., Arch. Biochem. Biophys. 152: 199-215 (1972); and M. Persans, et al., Plant Physiol. 109: 1483-1490 (1995)). The results demonstrate the efficacy of the methods and compositions of the present invention for the enhancement of P450 enzyme complexes.
[0071] Methods. CPR substrates have been assayed on various tissues (e.g., U.S. Pat. No. 6,020,288); therefore, response to human CPR (hCPR) was examined under controlled conditions on live index organisms. The direct effects of substrates on hCPR were measured by preparation of microsomes for quantification against CPR and Cc. Controls included equal concentrations of each individual tr...
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