Cytochrome P450 enzyme complexes and methods of treatment using the same

a technology of cytochrome p450 and enzyme complex, which is applied in the field of living organism treatment methods and compositions, can solve the problems of population that is left without the ability to defend adequately against xenobiotics, unavoidable p450 inhibitors, etc., and achieve the effect of increasing the amount of p450:fmn enzyme complexes and improving nutrition

Inactive Publication Date: 2006-06-29
NONOMURA ARTHUR M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0018] As another specific aspect, the present invention provides methods for dietary supplements to come to the defense of humans against harmful xenobiotics whilst improving nutrition, pa

Problems solved by technology

On the other hand, inhibitors of P450 are also unavoidable.
Upon exposure to the strongest inh

Method used

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  • Cytochrome P450 enzyme complexes and methods of treatment using the same

Examples

Experimental program
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Effect test

example i

[0062] First Exemplary Composition: FMN

Concentration per doseCompositionBroad RangeNarrow RangeFMN0.01-50mg3-5mgCod liver oil1-2500mg100-1000mg

[0063] Second Exemplary Composition: Drink

Concentration per 100 ml doseCompositionBroad RangeNarrow RangeXylose0.1-1%1-1000 gFMN1-1000 ppm1 mcg-5 mg

[0064] Third Exemplary Composition

ConcentrationCompositionBroad RangeNarrow RangeFMN0.01-20mg1-5mgAnalgesics1-2000mg5-100mg

[0065] Fourth Exemplary Composition

ConcentrationCompositionBroad RangeNarrow RangeFMN  1-5 mg 2-5 mgNADP10-100 mg10-50 mgBicarbonateexcipientexcipient

[0066] Fifth Exemplary Composition

ComponentDoseRangeFMN5 mg1-5 mgLiver extract1 mg10 mcg-2 g

[0067] Sixth Exemplary Composition: Drink

ConcentrationCompositionBroad RangeNarrow RangeFMN1 mcg-50 mg10 mcg-5 mgD-Xylose1-1000 g5-50gEtOHexcipientexcipientCarbon dioxideexcipientexcipientWaterexcipientexcipient

[0068] Seventh Exemplary Composition: Natural Sweetener Suitable for People with Diabetes

ConcentrationCompositionBro...

example 2

[0070] The following example illustrates an application of human P450 compositions according to the present invention. Procedures followed previously described methods, e.g., U.S. Pat. No. 6,020,288; M. Markwell, et al., Methods of Enzymology 72: 296-303 (1981); C. A. Mihaliak, et al., Methods in plant biochemistry 19: 261-279 (1993); R. Donaldson, et al., Arch. Biochem. Biophys. 152: 199-215 (1972); and M. Persans, et al., Plant Physiol. 109: 1483-1490 (1995)). The results demonstrate the efficacy of the methods and compositions of the present invention for the enhancement of P450 enzyme complexes.

[0071] Methods. CPR substrates have been assayed on various tissues (e.g., U.S. Pat. No. 6,020,288); therefore, response to human CPR (hCPR) was examined under controlled conditions on live index organisms. The direct effects of substrates on hCPR were measured by preparation of microsomes for quantification against CPR and Cc. Controls included equal concentrations of each individual tr...

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Abstract

The present invention provides methods and compositions for balancing electron reduction potentials of formulations in a manner that reduces susceptibility to changes from xenobiotics. The present invention also provides novel compositions of matter based on structuring from a mobile nucleotide integral to its architecture.

Description

[0001] This application claims priority of provisional application Ser. No. 60 / 638,918, filed Dec. 23, 2004, the disclosure of which is hereby incorporated by reference.BACKGROUND OF THE INVENTION [0002] The present invention relates generally to methods and compositions for treating living organisms. [0003] Upon utilization of a nanoscalar particle to achieve a practical purpose, its design and replication defines the field of nanotechnology. Indeed, over the past decade, inventions of biomaterials have focused on synthesis, while purposeful in vivo applications have gone wanting. Developments have resulted from the fabrication of novel architectures that range from Bucky Balls to octahedral DNA. Cytochromes offer some special nanometric advantages that are realized as a result of architecture elucidated within the current invention A diversity of cytochromes present possibilities for multitudes of combinations. For example, linkage of chemical reduction of dioxygen to electrogenic...

Claims

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Application Information

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IPC IPC(8): A61K38/44C12N9/02A23K1/165
CPCA23L1/3008A23L1/3012A23V2002/00C12N9/0077A23V2200/328A23V2250/638A23V2250/264A61K35/60A61K2300/00A61K31/7072A23L33/12A23L33/13
Inventor NONOMURA, ARTHUR M.
Owner NONOMURA ARTHUR M
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