Altered Intracellular Localization of BRK/Sik Protein Tyrosine Kinase in Human Prostate Tumors

a technology of tyrosine kinase and human prostate cancer, which is applied in the field of animal detection methods of abnormal prostate conditions, can solve the problems of ineffective methods, large deleterious side effects, and difficult treatment of prostate cancer
US20070037229A1Inactive Publication Date: 2007-02-15THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS
Publication Date
2007-02-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides methods for detecting abnormal prostate conditions, such as benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia (PIN), and adenocarcinoma, in an animal by comparing the amount of the Breast Tumor Kinase (BRK) tyrosine kinase in the nuclei of prostate luminal epithelial cells in a test sample with an amount of nuclear BRK protein in epithelial cells of normal prostate glands.
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Description

[0001] This application is related to U.S. provisional application Ser. No, 60 / 347,720, filed Jan. 11, 2002.

[0002] This invention was made with government support under DK44525 and DK068503 awarded by the National Institutes of Health. The government has certain rights in the invention.FIELD OF THE INVENTION

[0003] The invention relates to methods for detecting an abnormal prostate condition in an animal, Specifically, the invention relates to methods of detecting an abnormal prostate condition in an animal by detecting the amount of Breast Tumor Kinase (BRK) protein present in the nuclei of prostate luminal epithelial cells within a prostate tissue sample compared with the amount of BRE protein in the nuclei of normal prostate luminal epithelial cells. The invention further relates to methods for detecting prostate cancer in an animal by identifying prostate tissue samples wherein luminal epithelial cells in the sample do not display BRK nuclear localization BACKGROUND OF THE INVEN...

Claims

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