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Softgel of NLKJ for treating prostate diseases

a prostate disease and softgel technology, applied in the field of softgels, to achieve the effect of enhancing the

Active Publication Date: 2010-06-03
LI DAPENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The invention provides a softgel of NLKJ for the treatment of prostate diseases, including cancer. The softgel contains NLKJ and an antioxidant, such as Vitamin E. The recommended daily dosage is 0.1-1.0 g per kg of body weight, divided into 3-4 times a day. The use of the NLKJ softgels in combination with the injection of leuprolide acetate (Lupron®) has shown promising results in inhibiting the growth of prostate cancer. The combination therapy is more effective than either treatment alone. The softgel is easy to administer and has a higher curative effect."

Problems solved by technology

However, in previous documents, neither softgel of NLKJ nor the application thereof in treating prostate diseases was described.

Method used

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  • Softgel of NLKJ for treating prostate diseases

Examples

Experimental program
Comparison scheme
Effect test

experiment examples

Experiment Example 1

[0016] Inhibition of NLKJ softgels on the growth of human prostate cancer in an animal model

[0017] Experiment Drug:

[0018] NLKJ softgels (NLKJ for injection), Patch No. 20010412;

[0019] Kanglaite Injection (Product of Zhejiang Kanglaite Pharmaceutical Co. LTD, containing NLKJ 10 g / 100 ml), Patch No. 0011281-1.

[0020] Experiment Animal:

[0021] 30 male BALB / C nude mice (SPF grade), weighted 17-18 g, provided by Shanghai Tumor Institute (Certification of Quality No. 02-30-1 Sh. Med. Anim.).

[0022] Grafting Tumor: Human prostate cancer (PC-3M), subcultured by Pharmacological Department, Shanghai Institute of Medical Industries.

[0023] Experiment Method:

[0024] Well grown PC-3M tumors were homogenized in normal saline (1:4). The nude mice were inoculated subcutaneously in the axilla with 0.2 ml / mouse of the homogenate, then grouped randomly as follows:

[0025] 1) Control Group (Normal saline);

[0026] 2) NLKJ softgel (5 ml / kg, p.o.×10 d);

[0027] 3) NLKJ softgel (10 ml...

experiment example 2

[0034] Inhibition of NLKJ softgels in combination with Lupron on the growth of human prostate cancer in animal models

[0035] Experiment Drug:

[0036] NLKJ softgels (NLKJ for injection), Patch No. 011209;

[0037] Lupron (Takeda Chemical Industries, Ltd., Osaka, Japan 541), Patch No. 47978 AP.

[0038] Experiment Animal:

[0039] Male BALB / C nude mice (SPF grade), weighted 19-21 g, provided by Shanghai Tumor Institute (Certification of Quality No. 02-30-1 Sh. Med. Anim.).

[0040] Grafting Tumor: Human prostate cancer (PC-3M), subcultured by Pharmacological Department, Shanghai Institute of Medical Industries.

[0041] Experiment Method:

[0042] Well grown PC-3M tumors were homogenized in normal saline (1:4). The nude mice were inoculated subcutaneously in the axilla with 0.2 ml / mouse of the homogenate, then grouped randomly as follows:

[0043] 1) Control Group (Normal saline);

[0044] 2) NLKJ softgel (5 ml / kg, p.o.×10 d);

[0045] 3) NLKJ softgel (10 ml / kg, p.o.×10 d);

[0046] 4) Lupron (0.75 mg / kg, ...

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Abstract

A softgel of NLKJ for the treatment of prostate diseases, comprising 0.05˜1.0 g of NLKJ and 0.05˜1.5 mg of an antioxidant, said NLKJ having the following physicochemical parameter: acid value<0.56, iodine value 95.0-107.00, saponification value 185.00-195.00, specific gravity 0.914-0.918 (20° C.), and refractive index 1.470-1.475 (20° C.). The inhibition of the softgel of NLKJ on the growth of prostate cancer in combination with the injection of Lupron is stronger than that of each of them used alone.

Description

BACKGROUND OF THE INVENTION [0001] The invention refers to a softgel. More specially, the invention refers to a softgel of neutral lipids obtained from kernels of Job's tears for the treatment of prostate diseases. [0002] Neutral lipids obtained from kernels of Job's tears (Coix lacryma-jobi) (abbreviated to NLKJ hereinafter) having anti-tumor activities and enhancing immunological functions were disclosed in Chinese Patent 93117605.0. An emulsion of NLKJ mainly used via intravenous or intraartery injection was disclosed in Chines Patent 93100735.6. Neutral lipids from kernels of Job's tears and the anti-tumor pharmaceutical composition containing same were disclosed in U.S. Pat. No. 5,444,089. Neutral lipids from kernels of Job's tears, a process for the preparation thereof and the pharmaceutical composition containing same were disclosed in European Patent 0 588 621. However, in previous documents, neither softgel of NLKJ nor the application thereof in treating prostate diseases w...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/355A61K31/225A61K9/48A61K31/22A61K31/231A61K36/8994A61P13/08A61P35/00
CPCA61K9/48A61K31/22A61K31/231A61K36/8994A61K2300/00A61P13/08A61P35/00A61P43/00
Inventor LI, DAPENG
Owner LI DAPENG
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