Methods and Compositions for Testing and Breeding Cattle for Improved Fertility and Embryonic Survival

a technology for breeding and fertility, applied in the field of methods of genetic testing of cattle, can solve problems such as the decline in the fertility of dairy cattle, and achieve the effect of increasing the fertilization rate and the pregnancy rate of cattl

Inactive Publication Date: 2010-07-22
WISCONSIN ALUMNI RES FOUND
View PDF2 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0010]The present inventor investigated the effects of various genes of the IFNT signaling pathway and discovered that several of these genes comprise SNPs that are correlated with increased fertilization rate, or embryo survival rate, or both, and these SNPs may be used in breeding programs or other cattle testing or selection programs for cattle with improved fertility, more specifically for increased pregnancy rate in cattle. Accordingly, in one embodiment, the present invention provides a collection, or an array, of at least two of isolated polynucleotide molecule species selected from the group consisting of (1) an isolated polynucleotide comprising at least 12 consecutive nucleotides surrounding position of 1296 of SEQ ID NO:1; (2) an isolated polynucleotide comprising at least 12 consecutive nucleotides surrounding position of 213 of SEQ ID NO:2; (3) an isolated polynucleotide compris

Problems solved by technology

Such restructuring of the dairy cattle genome over the past 30 years due to intense selection for production traits may have resulted in a hitchhiking effect on a large number of loci adversely affecting fertilization rate and embryo survival, lead

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Methods and Compositions for Testing and Breeding Cattle for Improved Fertility and Embryonic Survival
  • Methods and Compositions for Testing and Breeding Cattle for Improved Fertility and Embryonic Survival
  • Methods and Compositions for Testing and Breeding Cattle for Improved Fertility and Embryonic Survival

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020]It has now been found that many genes encoding proteins of the IFNT signaling pathway contain single nucleotide polymorphisms (SNPs), and certain of these alleles correspond to increased fertilization rate, or embryonic survival rate, or both, in dairy cattle, and the beneficial effects of these alleles are additive. Specifically, it has been discovered that SNPs exist in the following genes: growth hormone receptor (GHR), osteopontin (OPN / SPP1), POU1F1, signal transducer and activator of transcription (STAT1), signal transducer and activator of transcription (STAT5A), bovine uterine milk protein (UTMP), and fibroblast growth factor 2 (FGF2).

[0021]These SNPs are summarized in the Table 1 below.

TABLE 1Gene Names, SNP Locations, and PolymorphismsSNPOriginally ReportedPolymorphicDesiredGenePositionNucleotideNucleotideNucleotideUTMP1296AGASTAT1213TCCOPN8504TCTGHR154,963TAAPOU1F1577CAAFGF2 SNP2323GTGFGF2 SNP1164611646AGGSTAT5A12195CGCGene Names, Chromosomal Locations, and Reference...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Currentaaaaaaaaaa
Crystal polymorphismaaaaaaaaaa
Login to view more

Abstract

Disclosed are arrays of nucleic acid molecules, kits, methods of genotyping and marker assisted bovine breeding methods using SNPs on genes of the bovine interferon tau signaling pathway for improved bovine fertilization rate, or embryo survival, or both.

Description

FIELD OF THE INVENTION[0001]The present invention relates to methods of genetic testing of cattle using molecular genetic methods by assaying for the presence of at least one genetic marker which is indicative of fertility or embryonic survival.BACKGROUND OF THE INVENTION[0002]Dairy cows are significant investments for dairy farmers, and enormous efforts, such as animal breeding and artificial insemination, have been and continue to be invested in ensuring that the animals have high and sustained productivity, and that the milk produced is of high quality. About 50 quantitative trait loci (QTL) affecting milk production traits have been identified (Bagnato et al., 2008; Lipkin et al., 2008). The dairy cattle genome has been significantly restructured over the past 30 years due to intense selection for production traits.[0003]Such restructuring of the dairy cattle genome over the past 30 years due to intense selection for production traits may have resulted in a hitchhiking effect on...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61D19/04C40B40/06C40B50/14C40B30/04A01K67/00A61D19/00A61D19/02A01K67/02
CPCC12Q1/6883C12Q2600/16C12Q2600/156
Inventor KHATIB, HASAN
Owner WISCONSIN ALUMNI RES FOUND
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap