Nutritional composition for infants delivered via caesarean section

a caesarean section and infant technology, applied in the field of infant feeding methods, can solve the problems of insufficient intestinal colonisation enabling the tolerability inducing effect of fermented milk alone, and achieve the effects of stimulating the growth of beneficial bacteria, reducing the incidence and severity of infections and/or diarrhoea, and fast colonisation of pathogenic bacteria

Inactive Publication Date: 2011-05-19
NV NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0016]The inventors recognized that early exposure of the intestine of the newborn infant that was delivered by caesarean section, to a milk-derived product which has been fermented by lactic acid producing bacteria, induces an intestinal tolerance for these bacteria similar to that of vaginally born infants, enabling a fast colonisation of the intestine as in vaginally born infants.
[0023]The presence of at least two different non-digestible oligosaccharides results in a microbiota that is more diverse in respect of different lactic acid producing bacteria species as is the case in vaginally born infants. The presence of at least two different non-digestible oligosaccharides and the milk-derived product obtained by fermentation with lactic acid producing bacteria act synergistically and advantageously results in a faster, as well as a higher as well as a more diverse colonisation with lactic acid producing bacteria, especially with lactobacilli and / or bifidobacteria.

Problems solved by technology

However, the tolerance inducing effects of the fermented milk alone is insufficient to enable a sufficient intestinal colonisation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Effect of Non-Digestible Oligosaccharides on the Microbiota in Caesarean Delivered Infants

[0112]Infants were administered infant formula supplemented with 0.72 g / 100 ml galacto-oligosaccharides (GOS) with an average DP between 2 and 7 and 0.08 g / 100 ml fructo-oligosaccharides with an average DP of above 20 (FOS, Raftilin HP®) (GFSF-group) or standard infant formula without non-digestible oligosaccharides (SF-group).

[0113]The bifidobacterial content in the faeces was determined. The percentage of the genus Bifidobacterium as a percentage of total bacteria in the first week was 4.3% in caesarean delivered infants (n=44) versus 19.8% in vaginally delivered infants (n=28). At 6 weeks the percentage bifidobacteria was 12.3% in the SF-group of caesarean delivered infants (n=21) and 17.2% in the GFSF-group of the caesarean infants (n=13). The faecal pH of the SF-group of caesarean delivered infants was 7.2 versus 6.5 of the GFSF-group of caesarean delivered infants. The percentage E. coli ...

example 2

Preparation of a Fermented Milk-Derived Product Comprising Inactivated B. breve

[0115]A fermented product with B. breve CNCM 1-2219 culture was obtained by a two steps process. A starter culture in the form of concentrated pellets was added to pasteurized skimmed milk and incubated for 8 h at 37° C. under anaerobic conditions. During the process the number of B. breve cells increased to about 3×109 cfu per ml and an acidification from about pH 6.7 to a pH of between 4.5 and 5.0 occurred, indicative for the process of fermentation taking place. Suitably cysteine in amount of 0.1 to 0.5 g per 1 and / or yeast extract in an amount of 0.5 to 5 g / l aqueous substrate, was present.

[0116]This fermented product was subsequently diluted 10 times into concentrated pasteurized skim milk (43 wt % dry matter) with a temperature of 37° C. The initial pH of the milk was reduced to 6-6.1 by this dilution step. After incubating for 8 h at 37° C., in a tank with periodic stirring for 10 minutes every 2 ...

example 3

Synergistic Effect of the Fermented Milk Derived Product Comprising Inactivated B. breve and Non-Digestible Oligosaccharides on Th1 Response Increase in a Murine Vaccination Model

Methods:

[0117]The effect of diets comprising (a) BbC50cf prepared according to example 2; (b) a combination of galacto-oligosaccharides (Elixor) and fructo-oligosaccharides (Raftilin HP); and (c) a combination of (a) and (b), were tested in a mouse model wherein a response to an antigen is measured by a delayed-type hypersensitivity (DTH) response. This DTH response in the ears after local challenge with an antigen present in a vaccine is a measure of Th1 cell proliferation. During response to infection and / or vaccination Th1 cells proliferate in response to the challenge with the antigen. These Th1 cells infiltrate the ear when the ear is subsequently challenged with the antigen and cause swelling. Infiltration with the Th1 cells in the ear takes about 24 h and the swelling is therefore delayed. The more T...

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Abstract

The present invention relates to methods for feeding of infants delivered via caesarean section and to compositions to be administered to infants delivered via caesarean section and in particular to the use of a product obtained by fermentation of milk, whey, whey protein, whey protein hydrolysate, casein, casein hydrolysate and / or lactose by lactic acid producing bacteria. Thereby it is possible to stimulate a fast colonisation of the intestinal microbiota of said infants.

Description

FIELD OF THE INVENTION[0001]The present invention relates to methods for feeding of infants delivered via caesarean section and to compositions to be administered to infants delivered via caesarean section.BACKGROUND OF THE INVENTION[0002]Before birth the intestinal tract of the infant is normally sterile. During vaginal delivery the intestinal tract of the infant is inoculated with vaginal and / or faecal bacteria of the mother, resulting in a colonization of the infant's gastrointestinal tract by bacteria originating from the mother. A maternal healthy intestinal microbiota has numerous positive effects on the infant, such as a reduced incidence of infections and a strengthened immune system.[0003]In infants delivered via caesarean section the colonization by intestinal bacteria is delayed and occurs by bacteria present in the hospital environment, resulting in the development of a different, less optimal intestinal microbiota. Grönlund et al, 1999, JPGN 28:19-25, disclose that ther...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K35/20A61P37/08A61P17/00A61P11/06A61P31/00A61P1/12A61P1/14A23L33/00A61K35/744A61K35/745
CPCA23L1/296A23L1/3014A23V2002/00A61K31/702A61K31/733A61K35/744A61K35/745A61K38/017A61K2300/00A23V2200/324A23V2200/3202A23V2200/3204A23V2250/28A23L33/40A23L33/135A61K38/018A61P1/12A61P1/14A61P11/06A61P17/00A61P29/00A61P31/00A61P37/00A61P37/04A61P37/08
Inventor SCHMITT, JOACHIMPERRIN, EMMANUELSTAHL, BERNDBOEHM, GUNTHER
Owner NV NUTRICIA
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