Catechol-based derivatives for treating or preventing diabetics

Abstract

The present invention provides a catechol-based derivative and a pharmaceutical acceptable salt therefrom and a solvate therefrom. A pharmaceutical composition for preventing or treating diabetes and ischemia, comprising a catechol-based derivative of formula (I) and at least one selected from the group consisting of a pharmaceutical excipient, a diluent and a carrier.

Description

CROSS REFERENCE TO RELATED APPLICATIONS[0001]This application is a Divisional Application of the Non-provisional application Ser. No. 12 / 368,167 filed Feb. 9, 2009, which is a Continuation-in-part Application of the International Application PCT / CN2006 / 001991 filed Aug. 7, 2006. The entire contents of these prior applications are hereby incorporated by reference.FIELD OF THE INVENTION[0002]The present invention relates to a compound having an antioxidant activity and the ability to prevent and treat diabetes or ischemia and the preparation thereof. More particularly, the present invention relates to a catechol-based derivative and the preparation thereof.BACKGROUND OF THE INVENTION[0003]There are currently 15.7 million people or 5.9% of the population in the United States who suffer from diabetes mellitus. Each day approximately 2,200 people are diagnosed with diabetes and roughly 798,000 people will be diagnosed this year. Diabetes is the seventh leading cause of death (sixth-leadi...

AI Technical Summary

Problems solved by technology

While diabetes is typically considered as a blood-sugar disease, diabetes may result in numerous life-threatening complications.

1. Type 1: Insulin dependent diabetes mellitus (IDDM), commonly referred to as Type 1 diabetes, is an auto-immune disease. Type 1 diabetes occurs when body's immune system attacks and destroys beta cells in the islets of Langerhans in the pancreas. Beta cells normally produce insulin. If the beta cells are destroyed, no insulin can be produced, and glucose stays in the blood, where high level of glucose can cause serious damage to all organ systems in the body. Type 1 diabetes may affect as many as 1 million people in the United States.

2. Type 2: Non-insulin dependent diabetes mellitus (NIDDM), commonly referred to as Type 2 diabetes, is a metabolic disorder resulting from body's inability to produce sufficient insulin or properly use the insulin produced. Type 2 diabetes is characterized by peripheral insulin resistance with an insulin-secretory defect that varies in severity. Roughly 90 percent of all diabetic individuals in the United States suffer from Type 2 diabetes, which is usually associated with obesity and a sedentary lifestyle.

3. Specific type: The aetiology of this type of diabetes, which is a secondary diabetes, can be traced to other diseases such as Hemochromatosis and Cushing's syndrome.

4. Gestational Diabetes

Ischaemic hear disease often results in acute myocardial infarction (AMI), a congestive heart failure, arrhythmia, and sudden death.

It is the most common cause of morbidity and mortality in most industrial countries.

Many patients noted above develop subsequent complications, which cause heart failures and deaths.

In recent years, the increase in aging population and other common complications, such as the obesity and the diabetes, puts a greater burden on public health budgets for ischaemic heart disease.

Therefore, how to effectively minimize ischemia and reduce injuries associated with reperfusion of ischaemic hearts has become an important medical issue.

However, the success in the treatment for cardiac arrest has been dismal in the past thirty years.

Although such treatments are helpful in preventing further deterioration of the ischaemic cardiac muscles, they may lead to complications.

Particularly, in high risk populations, surgery may lead to prolonged contractile dysfunction (or stunning), perioperative myocardial infarction, and cardiac failure.

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