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Compositions

a technology of compositions and sugars, applied in the field of pharmaceutical compositions, can solve the problems of small increases in the moisture content of such lozenges, affecting and unattractive and difficult to handle by packing equipment or users, and reducing the sugar content can compromise the physical hardness of lozenges. , to achieve the effect of reducing pain and discomfort, reducing the moisture content, and reducing the amount of sugar

Inactive Publication Date: 2014-02-06
RECKITT BENCKISER HEALTHCARE (UK) LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention relates to a flowable particulate composition that can be directly administered into the mouth. The composition avoids the issues associated with swallowing lozenges and provides a comfortable experience for the user. The composition can be easily dispensed in powdered or granulated form, without any risk of coughing or choking. The composition includes a bioadhesive material that improves the local effect of pharmaceutically active compounds in the mouth.

Problems solved by technology

However, small increases in the moisture content of such lozenges have the following detrimental effects.
Water causes the lozenge to become sticky and both unattractive and difficult to handle by packing equipment or by the user.
The reduction in the sugar content compromises the physical hardness of the lozenge.
For example, a much longer shelf life required of medicinal products, the health risks associated with chemical change mediated by increased water content, and the higher value of the goods spoiled.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0080]

ComponentQuantity (mg)FunctionFlurbiprofen8.750Active ingredientXylitol CM170315.000DiluentMannitol 100SD384.945DiluentCarbomer 974P25.500Bioadhesive / Granulation aidSodium bicarbonate, medium63.750EffervescentgranuleCool Mix for Mint 506070 TP050419.670FlavourPeppermint 201500 TP05045.100FlavourAspartame4.250SweetenerCitric acid anhyrous21.250EffervescentSilicon dioxide1.785Flow aidTotal850.00

example 2

[0081]

ComponentQuantity (mg)FunctionFlurbiprofen8.750Active ingredientXylitol CM170315.000DiluentMannitol 100SD359.945DiluentCarbomer 974P25.500Bioadhesive / Granulation aidSodium bicarbonate, medium63.750EffervescentgranuleFlavour24.770FlavourAspartame4.250SweetenerCitric acid anhyrous21.250EffervescentSodium Chloride25.000ExcipientSilicon dioxide1.785Flow aidTotal850.00

example 3

[0082]

ComponentQuantity (mg)FunctionFlurbiprofen8.750Active ingredientXylitol CM170315.000DiluentMannitol 100SD384.945DiluentCarbomer 974P25.500Bioadhesive / Granulation aidSodium bicarbonate, medium63.750EffervescentgranuleFlavour24.770FlavourAspartame4.250SweetenerCitric acid anhyrous21.250EffervescentSilicon dioxide1.785Flow aidTotal850.00

[0083]Flurbiprofen is a potent non-steroidal anti-inflammatory drug (NSAID), which has been shown to be efficacious in the treatment of sore throat in a number of phase II and phase III clinical studies.

[0084]Xylitol and mannitol are widely employed as pharmaceutical diluents. They also exhibit a cooling effect on dissolution in the mouth.

[0085]Carbomer is used in pharmaceuticals as a thickening or gelling agent, and forms very high viscosity gels at low concentrations and has good film forming properties. However, in the formulation of the present invention the primary role is to give a coating sensation when the product dissolves in the mouth. T...

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Abstract

An ingestible particulate composition including at least one compound selected from the group consisting of 2,4-dichlorobenzyl alcohol, amylmetacresol, cetylpyridinium chloride, hexitidine, hexylresorcinol, flurbiprofen, lidocaine, benzocaine, ibuprofen, paracetamol, pectin, menthol, and benzydamine and one or more bioadhesive materials. Resulting particulate compositions have excellent flow characteristics, dust suppression, organoleptic properties and stability. They are highly suitable for administration direction into a patient's mouth, and ingested to alleviate the symptoms of a sore throat.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. patent application Ser. No. 13 / 059,260, filed 25 Mar. 2011, which is a US National Stage of International Application No. PCT / GB2009 / 002014, filed 18 Aug. 2009, which claims the benefit of both GB 0900288.2, filed 9 Jan. 2009, and GB 0815405.6, filed 22 Aug. 2008, the entire contents and substance of which are each hereby incorporated by reference.BACKGROUND OF THE INVENTION 1. Field of Invention[0002]The present invention relates to pharmaceutical compositions, and in particular to pharmaceutical compositions for the treatment of sore throats.[0003]2. Background and Related Art[0004]Sore throats are often treated by sucking a sugar-based lozenge. The lozenge contains at least one compound which is active against sore throats. In addition, the sucking action results in the production of saliva which lubricates the throat and reduces the pain and discomfort experienced by an individual.[0005]A boi...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/00A61K9/14A61J1/03A61K31/192
CPCA61K9/006A61J1/035A61K9/14A61K31/192A61K9/0007A61K9/0056A61K9/1623A61K9/1635A61K9/1611A61P1/00A61P11/04A61P29/00A61K9/16A61K31/16A61K31/19
Inventor CAMPBELL, ALISTAIR
Owner RECKITT BENCKISER HEALTHCARE (UK) LTD
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