Kinase inhibitor and method for treatment of related diseases

a kinase inhibitor and related disease technology, applied in the field of kinase inhibitors and related diseases, can solve the problems of poor prognosis in adult patients

Active Publication Date: 2014-09-11
PEKING UNIV SHENZHEN GRADUATE SCHOOL +1
View PDF1 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0046]In another aspect of the present disclosure, it provides pharmaceutical compositions comprising a the...

Problems solved by technology

Acute lymphoblastic leukemia is the most common canc...

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Kinase inhibitor and method for treatment of related diseases
  • Kinase inhibitor and method for treatment of related diseases
  • Kinase inhibitor and method for treatment of related diseases

Examples

Experimental program
Comparison scheme
Effect test

examples

[0103]The following specific and non-limiting examples are to be construed as merely illustrative, and do not limit the present disclosure in any way whatsoever. Without further elaboration, it is believed that one skilled in the art can, based on the description herein, utilize the present disclosure to its fullest extent.

[0104]Synthesis of Compounds

[0105]Synthetic Scheme I

[0106]Step 1:

[0107]m-phenylenediamine (0.500 g, 4.62 mmol), (Boc)2O (0.92 mL, 4.02 mmol) and triethylamine (1.4 mL, 9.98 mmol) were added to a mixed solvent system of 1,4-dioxane and water (30 mL, 2:1 V / V) that has been cooled to 0° C. After stirring for 1 hour at 0° C., the reaction system was recovered to room temperature and stirred for another 10 hours. The reaction solution was concentrated under reduced pressure to yield yellow oil, which was dissolved in ethyl acetate, washed with saturated sodium bicarbonate solution and then with saturated brine. The final organic phase was dried with magnesium sulfate...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

Disclosed is a compound of (aminophenylamino) pyrimidyl benzamides and a synthesis method thereof. The compound has Btk-inhibition activity and can be used to treat autoimmune diseases, heteroimmune diseases, cancers or thromboembolic diseases.

Description

FIELD OF THE INVENTION[0001]The present application provides the molecular structures of compounds of (aminophenylamino) pyrimidyl benzamides and synthesis methods thereof, as well as use of the compounds in inhibiting kinases and treating B-cell associated diseases.BACKGROUND OF THE INVENTION[0002]The kinase's action mechanism is to transfer phosphate groups from high-energy donor molecules (e.g., ATP) to specific molecules, which is a process called phosphorylation. Protein kinases alter the activities of specific proteins through phosphorylation so as to control and regulate protein-associated signal transduction and other effects on cells. Due to the importance of protein kinases in cell signaling, the selectivity of some small molecule compounds for specific kinases will be helpful for further understanding on the cell signaling process. Meanwhile, small molecule compounds control the functions of cells by modulating the activities of kinases, which makes protein kinases become...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07D239/48C07D413/12C07D405/12
CPCC07D239/48C07D413/12C07D405/12A61P7/02A61P9/10A61P29/00A61P35/00A61P37/00A61P37/02A61P37/08A61P43/00C07D407/12
Inventor PAN, ZHENGYINGLIN, XIATO
Owner PEKING UNIV SHENZHEN GRADUATE SCHOOL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap