Prodrugs of Anti-platelet agents

Abstract

The invention relates to the compounds of formula II, formula Ia, formula IIa or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula II, formula Ia, formula IIa and methods for treating or preventing atherothrombosis may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment or management of ischemia, stroke, cerebral thrombosis, arterial thrombosis, thrombotic cerebrovascular, cardiovascular diseases and blood clots.

Description

PRIORITY[0001]This application is a Divisional application of and claims priority to the U.S. Non-Provisional application Ser. No. 14 / 533,120 titled “PRODRUGS OF ANTI-PLATELET AGENTS” filed on Nov. 5, 2014. The U.S. Non-Provisional application Ser. No. 14 / 533,120 further claims priority to the Patent Cooperation Treaty (PCT) application # PCT / IB2013 / 052328 titled “PRODRUGS OF ANTI-PLATELET AGENTS” filed on Mar. 24, 2013 Published with WIPO Publication # WO / 2013 / 168024, which further claims priority to Patent Cooperation Treaty (PCT) application # PCT / IB2012 / 053673 filed on Jul. 19, 2012, which further claims priority to patent application 1781 / CHE / 2012 filed on May 7, 2012 in the country of India. The entire disclosure of the priority applications are relied on for all purposes and is incorporated into this application by reference.FIELD OF THE INVENTION[0002]This disclosure generally relates to compounds and compositions for the treatment of atherothrombosis. More particularly, thi...

AI Technical Summary

Problems solved by technology

This common pathophysiologic process results in morbid or fatal clinical ischemic events affecting the cerebral, coronary, or peripheral arterial circulation.

However, there is controversy regarding choice of oral antiplatelet therapy in patients with vascular diseases (ie, ischemic stroke, coronary artery disease [CAD], and peripheral arterial disease [PAD]).

While it has been established that aspirin prevents recurrent atherothrombotic events across a wide range of high-risk patients (relative risk reduction of approximately 25%), it is less clear if other antiplatelet agents, such as clopidogrel or dipyridamole, alone or added to aspirin, are more effective.

This uncertainty This uncertainty is reflected in clinical practice: neurologists prefer to use aspirin combined with dipyridamole for patients with transient ischemic attacks (TIAs) or ischemic strokes; cardiologists use aspirin, clopidogrel, or their combination for patients with CAD; and there are few data regarding optimal antiplatelet treatment choices in patients with PAD.

The potential for increased hemorrhagic risk, especially in the surgical setting.

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