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Small molecule ligand-drug conjugates for targeted cancer therapy

a cancer therapy and small molecule technology, applied in the direction of antineoplastic agents, medical preparations, pharmaceutical non-active ingredients, etc., can solve the problems of no effective treatment, type of targeting approach, and promising results, and achieve the effect of improving clinical efficacy and translational valu

Inactive Publication Date: 2016-10-27
EMORY UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a method to remove cancer cells from a patient's body. This is done by giving the patient a small molecule that targets cancer cells and prevents them from spreading and growing. This approach minimizes the risk of cancer coming back after treatment.

Problems solved by technology

Most deaths from cancer are caused by metastasis for which there is no effective therapy.
Unfortunately, because of the heterogeneity and evolutional properties of cancer cell surface biomarkers and the bulky chemical structures of the targeting ligands, this type of targeting approach, although promising, remains a challenge from both technical and translational points of view.

Method used

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  • Small molecule ligand-drug conjugates for targeted cancer therapy
  • Small molecule ligand-drug conjugates for targeted cancer therapy
  • Small molecule ligand-drug conjugates for targeted cancer therapy

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Abstract

The present invention describes small molecule ligand-drug conjugates and methods of using the small molecule ligand-drug conjugates for targeted treatment of cancer in a patient in need thereof. Further described are methods of sterilizing circulating tumor cells and determining drug concentration in cancer tissue.

Description

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT[0001]This invention was made with government support under Grant number 0748834 awarded by the National Science Foundation and Grant number CA-119338 from the National Cancer Institute. The government has certain rights in the invention.BACKGROUND OF THE INVENTION[0002]Cancer is the second leading cause of death in the US. Most deaths from cancer are caused by metastasis for which there is no effective therapy. Improved drug delivery to cancer cells is critical for the development of effective chemotherapy in patients. One approach is to synthesize chemical conjugates of promising drugs with a targeting ligand that recognizes a unique biomarker on the surface of a cancer cell. Unfortunately, because of the heterogeneity and evolutional properties of cancer cell surface biomarkers and the bulky chemical structures of the targeting ligands, this type of targeting approach, although promising, remains a challenge from both...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K47/48A61K49/00
CPCA61K47/48061A61K49/0032A61K49/0052A61K49/0002A61K47/545A61K47/546A61P35/00
Inventor CHUNG, LELAND W.K.YANG, XIAOJIANCHENG, JIANJUNTONG, RONGHENARY, MAGED
Owner EMORY UNIVERSITY