Cd147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia

a technology of cd147 and pilus, which is applied in the direction of peptides, biological material analysis, dna/rna fragmentation, etc., can solve the problems of difficult identification of molecular determinants involved in direct interaction with host cell receptors using a genetic approach, and achieve the effects of preventing primary attachment of meningococci, preventing bacterial meningitis and/or purpura fulminans, and preventing meningeal
US20180340017A1Inactive Publication Date: 2018-11-29INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM) +1
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM)
Publication Date
2018-11-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention concerns the use of an inhibitor of an interaction between type IV pilus-associated protein and CD147 for preventing or treating meningoccal bacteraemia and / or infection. The present invention also relates to the combined use of such inhibitor and of an anti-bacterial compound, such as one used to prevent or treat a meningococcal infection. The invention also relates to a method for the prevention and / or treatment of meningococcal bacteraemia and / or infection, and to a method for screening inhibitors of the interaction between type IV pilus-associated protein and CD147.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a divisional application of U.S. Ser. No. 14 / 405,444, having a filing date of Dec. 4, 2014, which was a 371 application of International application PCT / EP2013 / 064900 filed on Jul. 15, 2013, which claimed the benefit of European patent application 12305920.6, filed Jul. 27, 2012, all of said applications incorporated herein by reference.FIELD OF THE INVENTION

[0002] The present invention concerns the use of an inhibitor of an interaction between type IV pilus-associated protein and CD147 for preventing or treating meningococcal bacteraemia and / or infection. The present invention also relates to the combined use of such inhibitor and of an anti-bacterial compound, such as one used to prevent or treat a meningococcal infection. The invention also relates to a method for the prevention and / or treatment of meningococcal bacteraemia and / or infection, and to a method for screening inhibitors of the interaction between type IV ...

Claims

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