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Antibodies against F glycoprotein of Hendra and Nipah viruses

a technology of hendra and nipah viruses, which is applied in the field of immunology, can solve the problems of limited information concerning the specific properties of isolated antibodies

Active Publication Date: 2018-05-29
THE HENRY M JACKSON FOUND FOR THE ADVANCEMENT OF MILITARY MEDICINE INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009]The present invention relates to antibodies or antibody fragments that bind, neutralize, and / or inhibit Hendra and / or Nipah virus. In particular, the present invention provides an antibody or fragment thereof that selectively binds a Hendra virus or Nipah virus F glycoprotein, wherein said antibody comprises: a heavy chain variable region comprising at least one complementarily-determining region (CDR) having the amino acid sequence selected from the group consisting of SEQ ID NO: 35, 37 and 39; and a light chain variable region comprising at least one CDR having the amino acid sequence selected from the group consisting of SEQ ID NO: 43, 45 and 47. The invention also provides a humanized antibody or antibody fragment selectively binding to a Hendra virus or Nipah virus F glycoprotein, wherein said antibody or antibody fragment comprises a heavy chain variable region having at least 90% sequence identity to SEQ ID NO: 33.

Problems solved by technology

These reports provide limited information concerning the specific properties of the isolated antibodies.

Method used

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  • Antibodies against F glycoprotein of Hendra and Nipah viruses
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  • Antibodies against F glycoprotein of Hendra and Nipah viruses

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Definitions

[0019]Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. See, e.g., Singleton P and Sainsbury D., Dictionary of Microbiology and Molecular Biology 3rd ed., J. Wiley & Sons, Chichester, New York, 2001, and Fields Virology 4th ed., Knipe D. M. and Howley P. M. eds, Lippincott Williams & Wilkins, Philadelphia 2001.

[0020]As used herein, the term “antibody” refers to an immunoglobulin molecule that may have the ability to specifically bind to a particular antigen. Antibodies may have different varieties known as isotypes or classes, such as but not be limited to the five basic antibody isotypes known as IgA, IgD, IgE, IgG and IgM. An antibody fragment may comprise a part of an immunoglobulin molecule or a combination of parts of immunoglobulin molecules. Antibody fragments may retain antigen binding ability. Antibody fragment may include antigen b...

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Abstract

The present invention relates to antibodies or antibody fragments that bind, neutralize, and / or inhibit Hendra or Nipah virus. The invention provides antibodies or antibody fragments that selectively bind to the F glycoprotein of Hendra or Nipah virus, and pharmaceutical compositions including such antibodies and / or fragments. The invention further provides polynucleotides encoding the antibodies and fragments of the invention and host cells transformed therewith. Additionally, the invention discloses prophylactic, therapeutic, and diagnostic methods employing the antibodies, fragments, polynucleotides, and / or compositions of the invention.

Description

GOVERNMENT LICENSE RIGHTS[0001]This invention was made with government support under AI 077995 and AI 054715 awarded by National Institutes of Health (NIH). The government has certain rights in the invention.SEQUENCE LISTING SUBMISSION VIA EFS-WEB[0002]A computer readable text file, entitled “044508-5048-SequenceListing.txt” created on or about Jul. 20, 2016 with a file size of about 45 kb contains the sequence listing for this application and is hereby incorporated by reference in its entirety.FIELD OF THE INVENTION[0003]This invention relates generally to the field of immunology and specifically to antibodies and antibody fragments that bind to Hendra and Nipah viruses and / or inhibit Hendra and Nipah virus activities.BACKGROUND OF THE INVENTION[0004]Nipah virus (NiV) and Hendra virus (HeV) are closely related paramyxoviruses that comprise the Henipavirus genus (Anonymous 1999 MMWR Morb Mortal Wkly Rep Ward, J. W. ed. 48:335-337; Chew, M. H. et al. 2000 J Infect Dis 181:1760-1763; ...

Claims

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Application Information

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Patent Type & Authority Patents(United States)
IPC IPC(8): C07K16/10
CPCC07K16/1027C07K2317/21C07K2317/24C07K2317/34C07K2317/92C07K2317/55C07K2317/565C07K2317/569C07K2317/76C07K2317/51A61P31/14A61P43/00A61K39/42C07K2317/622A61K2039/505
Inventor CHAN, YEE-PENGBRODER, CHRISTOPHER C.
Owner THE HENRY M JACKSON FOUND FOR THE ADVANCEMENT OF MILITARY MEDICINE INC
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