Antibodies against F glycoprotein of Hendra and Nipah viruses

a technology of hendra and nipah viruses, which is applied in the field of immunology, can solve the problems of limited information concerning the specific properties of isolated antibodies
US9982038B2Active Publication Date: 2018-05-29THE HENRY M JACKSON FOUND FOR THE ADVANCEMENT OF MILITARY MEDICINE INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Patents(United States)
Current Assignee / Owner
THE HENRY M JACKSON FOUND FOR THE ADVANCEMENT OF MILITARY MEDICINE INC
Publication Date
2018-05-29

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Abstract

The present invention relates to antibodies or antibody fragments that bind, neutralize, and / or inhibit Hendra or Nipah virus. The invention provides antibodies or antibody fragments that selectively bind to the F glycoprotein of Hendra or Nipah virus, and pharmaceutical compositions including such antibodies and / or fragments. The invention further provides polynucleotides encoding the antibodies and fragments of the invention and host cells transformed therewith. Additionally, the invention discloses prophylactic, therapeutic, and diagnostic methods employing the antibodies, fragments, polynucleotides, and / or compositions of the invention.
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Description

GOVERNMENT LICENSE RIGHTS

[0001] This invention was made with government support under AI 077995 and AI 054715 awarded by National Institutes of Health (NIH). The government has certain rights in the invention.SEQUENCE LISTING SUBMISSION VIA EFS-WEB

[0002] A computer readable text file, entitled “044508-5048-SequenceListing.txt” created on or about Jul. 20, 2016 with a file size of about 45 kb contains the sequence listing for this application and is hereby incorporated by reference in its entirety.FIELD OF THE INVENTION

[0003] This invention relates generally to the field of immunology and specifically to antibodies and antibody fragments that bind to Hendra and Nipah viruses and / or inhibit Hendra and Nipah virus activities.BACKGROUND OF THE INVENTION

[0004] Nipah virus (NiV) and Hendra virus (HeV) are closely related paramyxoviruses that comprise the Henipavirus genus (Anonymous 1999 MMWR Morb Mortal Wkly Rep Ward, J. W. ed. 48:335-337; Chew, M. H. et al. 2000 J Infect Dis 181:1760-1763; ...

Claims

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