Apparatus and method for the treatment of benign prostatic hyperplasia

Abstract

An apparatus and method for treatment of benign prostatic hyperplasia is disclosed wherein the apparatus includes an applicator having a probe having proximal and distal probe sections wherein the proximal and distal probe sections each define an axis and wherein the axes are not collinear.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS <?insert-end id="INS-S-00001" ?> [0001]The present application claims priority to U.S. Provisional Application No. 60 / 412,705 entitled “Apparatus and method for treatment of benign prostatic hyperplasia by electroporation”, which was filed Sep. 23, 2002. This application is a continuation-in-part of U.S. patent application Ser. No. 10 / 217,749 entitled “Apparatus and method for treatment of benign prostatic hyperplasia by electroporation”, which was filed Aug. 13, 2002 (U.S. Patent Application Publication 2003 / 0060856, published Mar. 27, 2003) now U.S. Pat. No. 6,994,706<?insert-start id="INS-S-00002" date="20101228" ?>, which claims the benefit of U.S. Provisional Application Ser. No. 60 / 325,994 filed Oct. 1, 2001 and U.S. Provisional Application Ser. No. 60 / 311,792, filed Aug. 13, 2001<?insert-end id="INS-S-00002" ?>.BACKGROUND OF THE INVENTION[0002]1. Field of the Invention[0003]The present invention relates generally to m...

AI Technical Summary

Benefits of technology

[0027]The hollow probe portion provides access for a plurality of electrodes and other desirable instrumentation to the prostate gland. For example, a pair of needle electrodes and an flexible fiber optic endoscope can be housed within the probe portion. If desired, separate passages or channels can be provided for the electrodes and the endoscope. The endoscope will preferably extend the length of the probe, from the probe proximal end to the probe distal end. The endoscope may be provided to enable the visualization of the urethra distally to the probe to enable safe placement and manipulation of the inventive apparatus during therapy procedures.

[0029]The curved probe portion serves to displace the proximal and distal portions from each other. In turn, this displacement displaces the prostatic urethral segment and the penile urethral segments from each other. The electrode needles can thus be advanced substantially parallel to the longitudinal axis of the proximal portion, and thus the penile urethral segment, into the prostate gland. Thus, this displacement facilitates ready and proper positioning of the needle electrodes into the prostate gland without the necessity of bending needles about 90 into the prostate gland and without the associated complicated structures found in the prior art. This probe geometry enables the needles to be placed into the prostate gland substantially parallel to the urethra, which in turn enables the use of fewer treatment positions and shorter treatments.

Problems solved by technology

The cause of death of an electroporated cell is believed to be a chemical imbalance in the cell, resulting from the fluid communication with the extra-cellular environment through the pores.

The irreversibly chemically imbalanced cell cannot repair itself by any spontaneous or biological process and dies.

At higher temperature cells are more vulnerable to cell death by electroporation.

Benign prostate hyperplasia can cause distressing urination symptoms.

Some symptoms of BPH stem from the gradual loss of bladder function leading to an incomplete emptying of the bladder.

These symptoms alone can negatively affect the quality of life of affected men.

Left untreated, BPH can cause even more severe complications, such as urinary tract infection, acute urinary retention, and uremia.

They can delay but not prevent the eventual need for surgery.

Regardless of the efficacy of any drug treatment, the long term exposure to xenobiotic compounds may produce additional unwanted side effects that are not realized until years after treatment.

Each of these procedures, however, suffers from one or more of the following deficiencies: high morbidity, long hospital stays, the use of general anesthesia, significant side effects such as impotence, and possible complications such as infection and inflammation.

While generally successful, the microwave and RF therapies are relatively long procedures.

Also, because of the poor temperature control of the heated volume, the volume of removed tissue is often not sufficient for the long term relief of the symptoms and / or the healthy tissue of the urethra is damaged.

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