2 results about "Lectin binding" patented technology

The application discloses a kind of based on nanomechanics fingerprint and one-dimensional convolutional neural network (deep learning) antiviral agglutinin rapid screening method, system and storage medium, belong to the cross technical field of biophysics, nanotechnology and artificial intelligence.This method realizes the in-situ capture of target virus and agglutinin binding reaction by constructing rigid seamless liquid phase atomic force microscopic measurement interface;Atomic force microscope is used to synchronously acquire the topographic image and force-distance curve of virus particle, and form multimodal nanometer characterization dataset.Extract the height, volume, roughness and other topographic features of virus by image processing algorithm, and extract the deep features of force spectrum signal combined with deep learning, input the multi-class feature vector into the prediction model after fusion, calculate the inhibition score of agglutinin and complete the activity sorting, so as to realize the rapid screening of high-activity candidate agglutinin.The application not only solves the interference of substrate instability and micro-bubble in liquid phase AFM measurement, but also significantly improves the efficiency and accuracy of antiviral drug screening, with good adaptability and popularization value.