45results about How to "Short modeling cycle" patented technology

An ice coating simulation method for a 220kV transmission line tower-coupling system is provided. The method comprises the following steps: (1) performing finite element modeling of an ice-covered transmission line tower-coupling system, including: modeling a tower by using a unit mirror command, modeling of an insulator and a split conductor spacer, and modeling of split sub-conductors and groundlines; (2) performing form-finding on the transmission line tower-coupling system; (3) calculating the ice-covered loads of the transmission line tower-coupling system; (4) calculating the ice-covered-wind loads of the transmission line tower-coupling system; and (5) performing response calculation and data extraction analysis under the ice coating. According to the method provided by the presentinvention, finite element modeling of the refined tower line is performed by using the unit mirror command, the modeling period is short, and the calculation efficiency is high; according to the actual arrangement manner of the split conductor, the coupling effect between the split sub-conductors is considered, and the model is more refined; and the analytical method and the finite element methodare combined to simulate the conductor, and the technical problems of finite element modeling and form-finding of the overhead line are solved.

The invention provides an establishment method of an endoplasmic reticulum stress induced mouse acute liver injury model. The establishment method orderly comprises the following steps: carrying out intragastric administration treatment on mice by use of an endoplasmic reticulum stress inducer with a dosage of 0.2ml/10g for each mouse, and completing the establishment of the mouse acute liver injury model in 8-48 hours after administration, wherein the endoplasmic reticulum stress inducer is prepared by a method comprising the steps of taking (0.5-4)mg of tunicamycin for dissolving 100 microliters of dimethyl sulfoxide to obtain a preservation solution, taking 100 microliters of preservation solution and adding 19.9ml of double distilled water to 20ml, and thus completing the preparation of the endoplasmic reticulum stress inducer. The mouse model of the induced acute liver injury is established by inducing the endoplasmic reticulum stress effect; through the study on the mechanism of action of the endoplasmic reticulum stress, the self regulation ability of cells in the stress state can be further known, and the occurrence mechanism of the liver diseases can be further known; therefore, new intervention and treatment measures can be adopted for the liver diseases to achieve the purposes of preventing and treating diseases.

The invention discloses a model for inducing drug resistance in a pseudomonas aeruginosa animal as well as a construction method and an application of the model. With the application of the model constructed by the method, better simulation of a phenomenon of PA infection in respiratory tract of a patient who accepts wide-spectrum antibiotics clinically for a long time can be achieved, and development and change rule of the drug resistance of pseudomonas aeruginosa in a mouse body can be observed, so as to simulate the change of the bacterium (the pseudomonas aeruginosa) in the body and to facilitate study on antibacterial drug-resistance medicine treatment; and meanwhile, the animal model, as a lung index evaluating animal model, is more intuitive, accurate in evaluating result, short in construction cycle and high in efficiency.

The invention discloses a method for establishing a skin-sensitized food allergy animal model, and belongs to the technical field of medical evaluation and detection. The method comprises an allergen sensitization stage and an allergen excitation stage, in the allergen sensitization stage, an MC903 ethanol solution containing OVA is smeared on the skin of an experimental animal, and in the allergen excitation stage, OVA dissolved in a buffer solution is used for intragastric administration excitation. The method of establishing the skin-sensitized food allergy animal model has the advantages of being easy and convenient to operate, short in modeling period, low in cost, good in reproducibility and the like.

The invention discloses a method for collecting and establishing a mine internal model based on HoloLens glasses. The method comprises the following steps that 1, mine internal structure information is collected by adopting a space mapping function of the HoloLens glasses; 2, the HoloLens glasses transmit a plurality of groups of mine internal structure information grids and photo information stored in the HoloLens glasses to a data processing computer; and 3, the data processing computer analyzes and processes the multiple groups of mine internal structure information grids and the mine innerwall photo information to obtain a mine internal 3D model. The method is simple in step, novel and reasonable in design, easy and clear to operate, good in universality, short in modeling period, good in modeling authenticity, high in practicability, good in using effect and convenient to popularize and use.

The invention discloses a method for screening genes related to early liver injury of passive smoking rats. By the method, a rat passive smoking model is established. Through a liver gene chip technology, differential genes of early liver injury in passive smoking rats were screened out, and functional annotation and analysis of the differential genes are performed, thus providing gene-level discovery and explanation for liver injury caused by smoking. The established rat passive smoking model has higher scientificity and stronger reliability, is accurate in controlling the concentration of poisoned smoke, has short modeling period, is of great clinical significance, and can realize early detection and early prevention.

The invention relates to the technical field of medical engineering, and particularly relates to a human-derived chordoma bone in-situ PDX model construction method and application thereof. The human-derived chordoma bone in-situ PDX model construction method comprises the steps that (1), chordoma patient tissue is selected; (2), the chordoma tissue is divided into three parts, one part is used for transcriptome sequencing, the other part is used for making a tissue chip, and the last part is implanted into the tibia medullary cavity of an immunodeficiency mouse; (3), the growth condition of the tibia tumor of the mouse is observed; (4), passage is conducted; and (5), the effectiveness and feasibility of the method are judged, and the method is used for detecting curative effect prediction and curative effect monitoring of potential new drugs. The method has the advantages that a model obtained through a chordoma construction method in the prior art cannot well simulate the disease characteristics and cannot well conduct drug screening to obtain effective drugs, the defects are overcome, and the model obtained through the construction method has the advantages of being high in simulation degree and good in feasibility.

The invention relates to a method for inducing a non-alcoholic fatty liver disease model through fluorine intervention. The method comprises the steps that high-fat diet is combined with fluorine intervention to induce the non-alcoholic fatty liver disease of an animal, the fat content in the high-fat feed is 45-60%, 0.01%-0.2% of sodium fluoride is added into the high-fat feed, or 50-1000 mg/L of sodium fluoride is added into drinking water of the animal, and the intervention period is 2-3 months. The non-alcoholic fatty liver disease animal model is high in modeling rate, stable in performance, low in cost and short in period, and the non-alcoholic fatty liver disease can be systematically and scientifically researched by utilizing the method.

The invention relates to a construction method of a mouse talaromyces marneffei latent reactivation model, which comprises the following steps: constructing a TM infected mouse, performing immunosuppression intervention on the TM infected mouse, and finally detecting the TM latent reactivation state of the mouse to realize the construction of the model. The talaromyces marneffei latent reactivation model of the mouse is successfully established for the first time, and the TM latent reactivation model is established in the mouse body, so that the dynamic process of fungi in the human body is simulated, and a model basis is provided for researching the latent infection state of TM in the body. And the TM latent activation model is used as a tool model for researching the TM, so that the molecular mechanism of TM latent infection can be further clarified conveniently, a sufficient basis and an early-stage basis are provided for analyzing the pathogenesis of the TM, a tool basis is also provided for deeply excavating the TM latent infection mechanism, and the research and development of related drugs in the field are promoted.

The invention discloses a method for constructing a urinary calculus animal model by using a locust, and belongs to the field of biomedicine. The method comprises the following steps of (1) injecting4-8 [mu]L of a copper chloride solution with the concentration of 5.0-10.5 mM into the abdominal cavity of the locust for the first time, and feeding the locust with fresh wheat seedlings under the conditions that the ratio of illumination time to darkness time is 13: 11 hours, the illumination temperature is (24-28)+/-2 DEG C, the darkness temperature is (20-26)+/-2 DEG C and the humidity is 60-85%; (2) injecting 4-8 [mu]L of the copper chloride solution into the abdominal cavity of the locust for the second time, and feeding the locust with the fresh wheat seedlings under the conditions thatthe ratio of illumination time to darkness time is 14: 10 hours, the illumination temperature is (24-28)+/-2 DEG C, the darkness temperature is (20-26)+/-2 DEG C and the humidity is 60-85%; and (3) after the locust injected with the copper chloride solution is subjected to physiological metabolism for 24-48 hours, gradually generating calcium oxalate crystals in different forms in a Markov tube.The method has the advantages of low material cost, good stability, controllable process and short period.

The invention provides a schisanhenol derivative with structures represented by general formulas (1), (2), (3) and (4), a preparation method and application thereof. According to the schisanhenol derivative, an active natural product schisanhenol is used as a substrate, and related groups are introduced to synthesize a series of schisanhenol derivatives; it is disclosed for the first time that theschisanhenol derivative has an obvious protective effect on concanavalin A induced HL-7702 human hepatocyte immune injury, it is prompted that the compound can be used for preparing liver protectiondrugs, and the liver protection effect is further explained through biological tests; schisanhenol in the raw materials mainly comes from dried ripe fruits of schisandra chinensis, and is rich in content, high in quality and low in price; and the preparation process is simple in steps, easy to operate and beneficial to large-scale production.