Rhodiola root glycosides injection for treating cardiovascular/cerebrovascular diseases and preparation method thereof

A technology for cardiovascular and cerebrovascular diseases and Tianglycoside injection, which is applied in the field of salidroside injection and its preparation for the treatment of cardiovascular and cerebrovascular diseases, and can solve the unseen problems in the development and application of salidroside in cardiovascular and cerebrovascular diseases Reporting and other issues to achieve the effect of avoiding the first-pass effect, facilitating rescue, and quick onset

Inactive Publication Date: 2007-09-19
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] After searching the prior art literature, there is no report on the development and application of salidroside alone in cardiovascular and cerebrovascular diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The composition and weight percentage of the salidroside injection are as follows: 0.2% salidroside, 0.5% sodium chloride, 0.2% chlorobutanol, and the balance is water for injection.

[0015] The preparation method is as follows: in a preparation container, add water for injection with a preparation amount of 80%, sequentially add salidroside, sodium chloride, and chlorobutanol in the above percentage by weight, stir to dissolve completely, add water for injection to 1000ml, with G 3 Filter through a vertically fused glass funnel, fill in a 2ml ampoule, and sterilize at 100°C for 30 minutes.

[0016] Implementation effect: the property is a colorless and clear liquid, the pH value is 5.5-6.5, the content of salidroside is 99.26% of the labeled amount, there is no local irritation, and other items meet the quality requirements of general injections stipulated in the Chinese Pharmacopoeia.

Embodiment 2

[0018] The composition and weight percentage of the salidroside injection are as follows: 2% salidroside, 1.5% sodium chloride, 0.5% chlorobutanol, and the balance is water for injection.

[0019] The preparation method is as follows: in a preparation container, add water for injection with a preparation amount of 80%, sequentially add salidroside, sodium chloride, and chlorobutanol in the above weight percentages, stir to dissolve completely, add water for injection to 1000ml, with G 3 Filter through a vertically fused glass funnel, fill in a 2ml ampoule, and sterilize at 100°C for 30 minutes.

[0020] Implementation effect: the property is a colorless clear liquid, the pH value is 5.4-6.5, the content of salidroside is 99.69% of the labeled amount, there is no local irritation, and other items meet the quality requirements of general injections stipulated in the Chinese Pharmacopoeia.

Embodiment 3

[0022] The composition of the salidroside injection and its percentage by weight: 1% salidroside, 1% sodium chloride, 0.3% chlorobutanol, and the balance is water for injection.

[0023] The preparation method is as follows: in a preparation container, add water for injection with a preparation amount of 80%, sequentially add salidroside, sodium chloride, and chlorobutanol in the above weight percentages, stir to dissolve completely, add water for injection to 1000ml, with G 3 Filter through a vertically fused glass funnel, fill in a 2ml ampoule, and sterilize at 100°C for 30 minutes.

[0024] Implementation effect: the property is a colorless clear liquid, the pH value is 5.3-6.4, the content of salidroside is 99.43% of the labeled amount, there is no local irritation, and other items meet the quality requirements of general injections stipulated in the Chinese Pharmacopoeia.

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PUM

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Abstract

Disclosed is a rhodiola root glycosides injection for treating cardiovascular / cerebrovascular diseases and preparation method, wherein the constituents (by weight portion) comprises salidroside 0.2-2%, sodium chloride 0.5-1.5%, chlorobutanol 0.2-0.5%, and balancing water for injection. And the preparing process comprises the steps of loading 80% water for injection into a preparation container, charging in turn salidroside, sodium chloride, chlorobutanol, stirring till complete dissolving, charging water for injection to 1000ml, filtering with G3 sintered glass funnel, imbedding into 2ml ampoule, sterilizing 30 minutes at 100 deg. C.

Description

technical field [0001] The invention relates to an injection in the technical field of medicine and a preparation method thereof, in particular to a salidroside injection used for injection for treating cardiovascular and cerebrovascular diseases and a preparation method thereof. Background technique [0002] Cardiovascular and cerebrovascular diseases are clinically common and frequently-occurring diseases. In recent years, with the improvement of people's living standards and the aging of the population structure, the incidence rate has been increasing year by year. The development of drugs for the treatment of cardiovascular and cerebrovascular diseases has been It has become a hot spot in drug research today. More and more clinical reports show that traditional Chinese medicine has good application prospects in the treatment of cardiovascular and cerebrovascular diseases. [0003] Rhodiola is the root and rhizome of the genus Rhodiola (Rhodiola L.) in the Sedum family. T...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7028A61K9/08A61P9/00
Inventor 贾伟赵爱华邱明丰谢国祥
Owner SHANGHAI JIAOTONG UNIV
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