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Process for preparing magnetic composite microball of monomer synthesizing biological degradable polyester kind

A technology of magnetic composite microspheres and biodegradable polyester, which is applied in the directions of non-active ingredients, such as medical preparations and pharmaceutical formulations, can solve the problem that the size of polyester magnetic composite microspheres is difficult to control, the content of iron tetroxide is not high, and the Weak magnetic responsiveness and other problems, to achieve good biocompatibility and biodegradability, high magnetic content, good stability

Inactive Publication Date: 2007-11-07
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to overcome the problems such as difficult control of the size of the polyester magnetic composite microspheres prepared by the physical embedding method in the prior art, wide particle size distribution, low ferroferric oxide content, weak magnetic responsiveness, etc., thereby A method for preparing biodegradable polyester magnetic composite microspheres by initiating polymerization of cyclic ester monomers on the surface of nano-Fe3O4 particles

Method used

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Embodiment 1

[0033] Preface

Embodiment 2

[0035]

Embodiment 3

[0037] Preface

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PUM

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Abstract

The invention discloses a manufacture method for magnetic compounding microballons that is covered by biology degradation polyester and uses magnetic Fe3O4. The feature is that it dispersing the cyclic ester class monomer, initiator and magnetic powder in organic solvent, using the active radical (-O-H, -NH2 and so on) coupling on the particle surface of nm Fe3O4 to take open loop polymerization on the magnetic particle surface of cyclic ester, the polyester magnetic compounding microballons that is covered with magnetic Fe3O4 to form core shell structure. The diameter of the invention could be controlled to 200-700 nm. It has high magnetic content, strong magnetic response, and stable microballons. The invention has widely application value in biology chemical field.

Description

technical field [0001] The invention belongs to the technical field of magnetic microsphere preparation, and in particular relates to a preparation method of biodegradable polyester magnetic composite microspheres, in particular to a method for preparing by initiating polymerization of cyclic ester monomers on the surface of nano ferric oxide particles A preparation method of biodegradable polyester magnetic composite microspheres. Background technique [0002] Polymer magnetic composite microspheres have both the characteristics of polymers and the magnetic responsiveness of magnetic substances. On the one hand, they can bind biologically active substances such as enzymes, cells, and antibodies through covalent bonds; magnetic responsiveness. Therefore, it is widely used as a carrier of enzymes, cells, drugs, etc. in the fields of biomedicine, cytology, and bioengineering. At present, the carrier materials of magnetic microspheres that have been studied more include polye...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/78C08K3/22C08L67/00A61K47/30
Inventor 任杰王佐滕新荣
Owner TONGJI UNIV
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