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Method and apparatus for tailoring spectroscopic calibration models

A technology for calibrating models and spectra, used in measurement devices, blood characterization devices, color/spectral property measurement, etc.

Inactive Publication Date: 2008-05-14
RIO GRANDE MEDICAL TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0021] The present invention fulfills these needs and solves problems associated with existing models and calibrations used in methods of non-invasively measuring biological properties such as blood glucose

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  • Method and apparatus for tailoring spectroscopic calibration models
  • Method and apparatus for tailoring spectroscopic calibration models
  • Method and apparatus for tailoring spectroscopic calibration models

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Embodiment Construction

[0063] Preferred embodiments of the present invention will be described in detail below. However, it should be understood that the disclosed embodiments are merely examples of implementing the invention in different systems. Therefore, the specific details herein are not to be construed as limitations of the invention, but as a basis for teaching one skilled in the art to practice the invention.

[0064] The present invention relates to a method for non-invasively measuring properties or properties of biological, eg tissue, analytes using spectroscopy. It has been found that the sample is a complex matrix of substances with different refractive indices and absorption properties. Furthermore, because the tissue or blood components of interest are at very low concentrations, it has been found necessary to incorporate a mathematical model using multivariate analysis. However, known methods for multivariate analysis of spectroscopic data from a large number of subjects do not yi...

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Abstract

A method and apparatus for non-invasively measuring a biological attribute, such as the concentration of an analyte, particularly a blood analyte in tissue such as glucose. The method utilizes spectrographic techniques in conjunction with an improved subject-tailored calibration model. In a calibration phase, calibration model data is modified to reduce or eliminate subject-specific attributes, resulting in a calibration data set modeling within-subject physiological variation, sample location, insertion variations, and instrument variation. In a prediction phase, the prediction process is tailored for each target subject separately using a minimal number of spectral measurements from each subject.

Description

[0001] This application is a continuation-in-part of US Patent Application Serial No. 09 / 170022 filed October 13,1998. technical field [0002] The present invention generally relates to a method for multivariate calibration and prediction, and its use in the non-invasive or non-destructive measurement of selected properties using spectroscopic methods. A specific implementation of the present invention relates to the case where biological tissue is irradiated with infrared energy having at least several wavelengths and the different amounts of absorbed by said biological tissue sample are measured using a multivariate calibration and prediction method Irradiated to determine an analyte concentration or other property of the tissue using the resulting spectral information to apply a calibration model. Background technique [0003] There is a well-documented need for an accurate non-invasive method for determining properties of tissue or other biological samples, or for deter...

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Application Information

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IPC IPC(8): G01N15/06G01N21/27A61B5/00A61B5/145A61B5/1455G01J3/28G01N21/35G01N21/3577G01N21/359
CPCA61B5/1455A61B5/1495A61B5/14532G01J3/28G01N21/359G01N21/31
Inventor E·V·汤马斯R·K·罗维
Owner RIO GRANDE MEDICAL TECH
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