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Method for preparing drop pills

A technology for the preparation and selection of dropping pills, which is applied in the fields of pill delivery, pharmaceutical formulations, and medical preparations of non-active ingredients, etc. Problems, to overcome the impact of pellet weight and pellet roundness, simplify the production process, control the difference in pellet weight and pellet roundness

Active Publication Date: 2008-11-12
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the pill-dropping machine currently used in industrial production is mainly a pill-dropping machine in which the drug liquid is naturally dripped from the mouth of the dripper by borrowing energy and gravity. The difference in pill weight is controlled by the thickness of the dropper caliber. If the drug solution is not filled enough, the difference in pill weight will increase. The control of pill weight and the roundness of the pellets are also affected by the physical properties, temperature, and selection of cooling liquid of the drug liquid, the distance between the dripper and the cooling liquid surface, and the temperature of the cooling liquid. The influence of factors such as the size of the droplet, the interfacial tension of the liquid medicine and the cooling liquid, the surface tension of the liquid medicine, and the thickness of the dropper tube wall make the weight difference of the dropping pills in the industrial production and the roundness of the pills difficult. The problem of control, the rate of qualified products is low, the production cost is high, and only drop pills with a pill weight below 70mg can be produced, which restricts the further development of drop pills

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Preparation of Wuzhi Dropping Pills: Take 1 part by weight of Schisandra Alcohol Extract and add it to 1 to 10 parts by weight of molten polyethylene glycol 6000 matrix, stir well to make a uniform medicinal solution, and heat it at 70°C to 90°C Next, use a quantitative pump to inject the liquid medicine into a spherical mold with a diameter of 2 mm to 10 mm, cool at a temperature of 45 ° C to 5 ° C, demould, and dry for 60 minutes at a temperature of 26 ° C and a relative humidity of 45%. Choose pills, count and pack, and you get it.

[0016] Compared with the dripping method, the average qualified product rate of the five-ester dripping pills prepared by the invention is increased by 12%, the average production cost is reduced by 21%, and the storage and shelf life is extended by 12 months under the same conditions.

Embodiment 2

[0018] Preparation of Yiganling Dropping Pills Take 1 part by weight of silymarin and add it to 1 to 5 parts by weight of molten polyethylene glycol 6000 matrix, stir well to make a uniform drug solution, and use quantitative The pump injects the liquid medicine into a spherical mold with a diameter of 2 mm to 6 mm, cools at a temperature of 40 ° C to 5 ° C, demoulds, and dries for 45 minutes at a temperature of 26 ° C and a relative humidity of 50%, and then screens and selects the pellets. , counting and subpackaging, that is to say.

[0019] Compared with the dripping method, the average qualified product rate of Yiganling dripping pills prepared by the invention is increased by 6%, the average production cost is reduced by 17%, and the storage and shelf life is extended by 6 months under the same conditions.

Embodiment 3

[0021] Preparation of Andrographolide Dropping Pills Take 1 part by weight of andrographolide and add it to 2 to 8 parts by weight of molten polyethylene glycol 6000 matrix, stir well to make a uniform medicinal solution, and store it at 70°C to 90°C under the condition of heat preservation. Use a quantitative pump to inject the liquid medicine into a spherical mold with a diameter of 2mm to 8mm, cool at a temperature of 40°C to 5°C, demould, dry for 30 minutes at a temperature of 26°C and a relative humidity of 45%, and sieve the pellets Select pills, count and pack, and you get it.

[0022] Compared with the dripping method, the average qualified product rate of the andrographolide dripping pills prepared by the invention is increased by 11%, the average production cost is reduced by 23%, and the storage and shelf life is extended by 6 months under the same conditions.

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Abstract

A process for preparing dripping pills features use of quantitative injection moulding method, resulting in high roundness, high qualified rate and high granularity.

Description

technical field [0001] The invention relates to a method for preparing dropping pills by quantitative injection molding. Background technique [0002] Dropping pills is to dissolve, emulsify or suspend the drug in a suitable molten matrix, and drop it into the immiscible cooling liquid through a suitable dropper. Made pills. [0003] Dropping pills first appeared in 1933. Danish pharmaceutical companies used this method to prepare vitamin A and D dropping pills; in 1956, PEG4000 was used as a substrate to prepare phenobarbital dropping pills; pill. The Chinese Pharmacopoeia has recorded the dosage forms of dropping pills since the 1977 edition. [0004] Dropping pills are especially suitable for making pills containing liquid medicines and small or irritating main medicines. It can increase the stability of medicines, reduce irritation, and cover up bad smells. It has the advantages of good hygiene and labor protection in the production workshop, and a shorter production ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K47/34A61K47/10
Inventor 刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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