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Sustained-release preparation containing hydrochlorothiazide and preparation method thereof

A technology of hydrochlorothiazide and sustained-release preparations is applied in the preparation of sustained-release preparations and in the field of sustained-release preparations of hydrochlorothiazide drugs, and can solve the problems of short duration of drug effect, low blood drug concentration, easy forgetting to take and missed doses, etc. The effect of stable drug concentration, reducing toxic and side effects, and reducing the number of administrations

Active Publication Date: 2010-01-20
HEFEI HEYUAN PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the fact that the drug release of ordinary tablets is too fast, the immediate blood drug concentration is too high, and the blood drug concentration is too low after short-term metabolism.
In addition, patients need to take it more than three times a day, which is extremely inconvenient, and it is easy to forget to take and miss a dose, which will affect the curative effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The following is the amount used in 1000 pieces

[0027] a. Hydrochlorothiazide immediate-release small tablets

[0028] Component Amount (g)

[0029] Hydrochlorothiazide 6

[0030] Microcrystalline Cellulose 10

[0031] Lactose 12.95

[0032] Crospovidone 0.9

[0033] Magnesium stearate 0.15

[0034] b. Hydrochlorothiazide extended-release small tablets

[0035] Component Amount (g)

[0036] Hydrochlorothiazide 31.5

[0037] Hydroxypropyl methylcellulose 12.5

[0038] Kabob 2

[0039] Lactose 8.725

[0040] Magnesium stearate 0.275

[0041] The preparation process is as follows:

[0042] The raw and auxiliary materials are crushed and sieved, mixed according to the above prescription amount, and then mixed with the lubricant. Squeeze them into small pieces, mix them and pour them into capsules.

Embodiment 2

[0044] The consumption of present embodiment is the amount used by 1000

[0045] a. Hydrochlorothiazide immediate-release small tablets

[0046] Component Amount (g)

[0047] Hydrochlorothiazide 6

[0048] Microcrystalline Cellulose 10

[0049] Lactose 12.95

[0050] Crospovidone 0.9

[0051] Magnesium stearate 0.15

[0052] b. Hydrochlorothiazide extended-release small tablets

[0053] Component Amount (g)

[0054] Hydrochlorothiazide 31.5

[0055] Hydroxypropyl methylcellulose K100 10.2

[0056] Kabob 9.6

[0057] Lactose 19.2

[0058] Magnesium stearate 0.3

[0059] The preparation method is the same as in Example 1.

Embodiment 3

[0061] The consumption of present embodiment is the amount used by 1000

[0062] a. Hydrochlorothiazide immediate-release small tablets

[0063] Component Amount (g)

[0064] Hydrochlorothiazide 6

[0065] Microcrystalline Cellulose 10

[0066] Lactose 12.95

[0067] Crospovidone 0.9

[0068] Magnesium stearate 0.15

[0069] b. Hydrochlorothiazide extended-release small tablets

[0070] Component Amount (g)

[0071] Hydrochlorothiazide 31.5

[0072] Hydroxypropyl methylcellulose K15 7.8

[0073] Carbopol 1.2

[0074] Lactose 19.2

[0075] Magnesium stearate 0.3

[0076] The preparation method is the same as in Example 1.

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PUM

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Abstract

The invention relates to pharmaceutical preparation field, specifically relates to sustained release medication of hydrochlorothiazide. The inventive sustained release medication comprises quick-release part and sustained release part. After the medicament getting in body, quick-release part quickly releases to get to certain blood concentration, slow-released part slowly releases to keep a certain blood concentration; thereby balancing pressure reducing effect. The invention also discloses the preparation method of the sustained release medication.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a sustained-release preparation of hydrochlorothiazide, and also discloses a preparation method of the sustained-release preparation. Background technique [0002] Hydrochlorothiazide is a diuretic. At the initial stage of medication, it is natriuretic and diuretic, which reduces blood volume and extracellular fluid, reduces cardiac output, and lowers blood pressure. After several weeks of continuous medication, the blood volume and cardiac output gradually recovered, and the blood pressure continued to decrease. At this time, the antihypertensive mechanism is the natriuretic and diuretic effect, which can reduce the sodium ion content in the arterial wall cells and reduce the endogenous response of vascular smooth muscle. The reactivity of vasoactive substances reduces the peripheral resistance and induces the production of vasodilators in the arterial wall. It can be...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/549A61K9/00A61K9/22A61K9/48A61K47/38A61K47/34A61K47/32A61K47/10A61K47/12A61K47/14A61P9/12A61P7/10
Inventor 高署
Owner HEFEI HEYUAN PHARM TECH CO LTD
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