Method for preparing highly water-soluble cydiodine

A cedidin, water-soluble technology, applied in the directions of active ingredients of iodine compounds, non-active ingredients of polymer compounds, drug combinations, etc., can solve the problems of long process, unsuitable for environmental disinfection, unsuitable for large-scale environmental disinfection and use, etc. To achieve the effect of fast coating

Inactive Publication Date: 2010-02-24
POULTRY INST SHANDONG ACADEMY OF AGRI SCI
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Problems solved by technology

In addition, in the above patents, the process of coating iodine with β-cyclodextrin is relatively long, that is, cediiodine can only be obtained after a certain period of time at the coating temperature.
[0004] The above patented methods can prepare cedi iodine with stable quality and high iodine content, but the solubility of cedi iodine prepared by these methods is very low, and the soluble amount in 100ml of water at 20°C is not more than 0.01g, which belongs to insoluble substances
Simultaneously, the cediodine prepared by these methods has other disadvantages and is not suitable for large-scale environmental disinfection.
For example, in the four patents of Japan and the patents of the Chinese Academy of Military Medical Sciences, I 2 The aqueous solution is made of KI as a cosolvent, and the amount of KI is the same as that of I 2 The dosage ratio is all very high, and KI is two-thirds of the iodine dosage in the patent of Japan, and KI is 0.2~10 times of the iodine dosage in the patent of my country Academy of Military Medical Sciences, because the price of KI and I 2 Similarly, KI has no bactericidal effect in cedi iodine, and the use of small doses can increase the solubility of iodine in water, but the use of large doses will only increase the cost of cedi iodine, which is not suitable for large-scale environmental disinfection
However, in the patent obtained by Chen Wenzheng of my country, only ethanol is used for the dissolving of iodine. The Sidi iodine prepared by this process not only has low solubility, but also has poor stability of the iodine molecules released by Sidi iodine in water due to the lack of dissolution aid of potassium iodide. , easy to volatilize and cause the concentration in water to decrease
[0005] As can be seen from the above patents: with I 2 With β-cyclodextrin coating ratio as 1: 1 calculation, the theoretical content of iodine molecules in cedi iodine is about 18.27%, because the solubility of cedi iodine prepared in the above patents is all lower than 0.01g, even if cedi iodine is dissolved in The iodine molecules coated after water are all dissociated, and the concentration of iodine molecules in the cedi iodine solution cannot reach 18.27mg / L, and the killing concentration of iodine to most bacteria will be higher than 50mg / L, so the above The cediodine prepared by the patented method will not be used as a large-scale disinfection

Method used

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  • Method for preparing highly water-soluble cydiodine

Examples

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example 1

[0038] Weigh 300g of β-cyclodextrin, add it into a glass reaction kettle with 1000ml of water, stir and heat it to 88°C-90°C and dissolve completely, then keep the temperature for later use. Weigh 67.1g of iodine and 5g of KI, add them to 200ml of 90% ethanol solution, and heat to 60°C to dissolve them all. Then, under stirring, the iodine solution was quickly added to the saturated solution of β-cyclodextrin, then the heating was stopped, and the reaction kettle was naturally cooled to 30°C under constant stirring. Then pour the reaction solution into a beaker and store it at room temperature for 24 hours to allow the cediiodine to precipitate naturally, then remove the supernatant, then put the precipitate in an enamel plate, and put it in an oven at 55°C to dry-bake until powdered. After sieving the powder, put it into an enamel plate and spread it evenly, then put it in the oven, raise the temperature of the oven to 120°C and maintain it for 40 minutes, mix the dry-baked c...

example 2

[0040] Weigh 200g of β-cyclodextrin, add it into a glass reaction kettle with 1000ml of water, stir and heat to 70°C to 72°C and dissolve completely, then keep the temperature for later use. Weigh 44.7g of iodine and 6g of KI, add them to 300ml of 95% ethanol solution, and heat to 50°C to dissolve them all. Under stirring, the iodine solution was quickly added to the β-cyclodextrin saturated solution, and then the heating was stopped, and the reaction kettle was naturally cooled to 35°C under constant stirring. After centrifuging the reaction solution with a continuous high-speed centrifuge with a rotation speed of 15000rps, the precipitate obtained by centrifugation was placed in an enamel plate, and put into an oven at 50°C to dry-bake until powdered. After sieving the powder, put it into an enamel plate and spread it evenly, then put it into the oven, raise the temperature of the oven to 130°C and maintain it for 30 minutes, mix the dry-baked cedi iodine evenly, and you can...

example 3

[0042] Weigh 500g of β-cyclodextrin, add it into a glass reaction kettle with 1500ml of water, stir and heat it to 80°C-82°C and dissolve completely, then keep the temperature for later use. Weigh 111.8g of iodine and 15g of KI, add them to 350ml of 80% ethanol solution, and heat to 60°C to dissolve them all. Under stirring, the iodine solution was quickly added to the β-cyclodextrin saturated solution, then the heating was stopped, and the reaction kettle was naturally cooled to 30°C under constant stirring. Then the reaction solution is spray-dried, the hot air temperature of the spray dryer is set at 160° C., the material outlet temperature is 70° C., and the cediodine is once spray-dried into powder. Put the cediodine into the enamel plate and spread it evenly, then put it into the oven, raise the temperature of the oven to 140°C and keep it for 15 minutes, and mix the dry-baked cediiodine evenly.

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Abstract

The invention discloses a preparation method of a high water-soluble cydiodine, which belongs to pharmacy technology field. Quickly putting the iodine solution into Beta- cyclodextrin saturated solution and then mixing constantly until the solution cools to below 40 DEG C. Then naturally precipitating the cooled cydiodine solution and pouring the supernatant out and leaving the sediment when the precipitation completes. Or separating the cooled cydiodine solution via centrifugation to separate the sediment and water, and then putting the sediment to the oven to bake to powder and then sift out; in addition, spray drying the cooled west ground solution to get dry powder of cydiodine is also feasible. Put the dry cydiodine powder to the oven to bake for a certain period and then mixing well,and the high water-soluble cydiodine will be formed. The high water-soluble cydiodine prepared by the method has the advantages of having fast coating speed, high water-soluble, good disinfect effectand stable quality.

Description

technical field [0001] The invention relates to a preparation method of highly water-soluble cedi iodine, which belongs to the technical field of pharmacy. Background technique [0002] Infectious diseases are one of the important factors that endanger the health of humans, animals and plants. In order to eliminate infection, we must not only kill pathogenic microorganisms that invade the body, but also eliminate pathogenic microorganisms in the environment to protect the health of humans, animals and plants, and this task must be completed by disinfection. Disinfection can eliminate pathogenic microorganisms from the source of infectious diseases and block the spread of pathogenic microorganisms, thereby protecting humans, animals and plants. Disinfection can be carried out by physical methods or chemical methods, and in the face of the epidemic of large infectious diseases, chemical disinfection is the most important means of disinfection. Chemical disinfection is the us...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/40A61K33/18A61P31/00
Inventor 何元龙杨英阁付剑赵增成吴建刚
Owner POULTRY INST SHANDONG ACADEMY OF AGRI SCI
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