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Cydiodine buccal tablet

A technology of cidi-iodine and buccal tablets, which is applied in the directions of iodine compound active ingredients, medical preparations of non-active ingredients, pill delivery, etc. Good, slow iodine content, slow reduction effect

Active Publication Date: 2005-07-20
浙江华润三九众益制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, after repeated experiments, we further found that due to the presence of citric acid, the iodine content of this patented preparation decreased rapidly, and the quality was difficult to control

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1. the preparation of the cediodine buccal tablet containing citric acid

[0037] composition:

[0038] Sidiiodine: 4.2g

[0039] Powdered sugar: 210g

[0040] Western brain: 18g

[0041] Citric acid (i.e. citric acid): 2.25g

[0042] Magnesium stearate: 2.25g

[0043] Binder: 17ml of 4% hydroxypropylmethylcellulose in water.

[0044] Weigh powdered sugar and pass through 80-mesh sieve, mix with cedi-iodine in equal increments, and dissolve citric acid in 3% HPMC as a binder. Pass through the soft material and granulate (granulate twice with a 16-mesh nylon sieve). Dry at 60°C for 2-3 hours, granulate with a 16-mesh nylon sieve, then add the prescribed amount of CD brain and magnesium stearate and mix well. After testing the content, use a φ11mm flat punch to press the tablet. After passing the inspection, carry out double aluminum packaging.

Embodiment 2

[0045] Embodiment 2. The preparation of cediodine buccal tablet of the present invention

[0046] composition:

[0047] (1) Sidiiodine: 4.2g

[0048] (2) Powdered sugar: 210g

[0049] (3) Western Brain: 18g

[0050] (4) Magnesium stearate: 2.25g

[0051] (5) Adhesive: 4% hydroxypropyl methylcellulose aqueous solution 17ml

[0052] Operation steps: except that citric acid is not added, other steps are the same as in Example 1.

Embodiment 3

[0053] Embodiment 3. The stability test of the cediodine buccal tablet of embodiment 1 and embodiment 2

[0054] batch number

[0055] The above experiments show that citric acid has an important influence on the stability of cediiodine. Just because citric acid is not contained in the cediiodine buccal tablet of the present invention, the stability is good and the iodine content decreases slowly.

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PUM

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Abstract

The present invention relates to a tabellae cydiodini lozenge. Said lozenge is formed from the following components: (by wt%) 1.8-5% of tabellae cydiodini, 1-8% of cydionaol, 0.5-1% of magnesium stearate, 80-95% of sugar powder or lactose and 0.01-3% of hydroxypropyl methyl cellulose. Said invented tabellae cydiodini lozenge contains no citric acid component, its stability is good and its iodine content reduction is slow.

Description

field of invention [0001] The invention relates to a buccal tablet of iodine (β-Cyelodextion Inclusion Compound of Iodine, referred to as β-cyclodextrin inclusion compound of iodine) for treating oral cavity and throat diseases. Background technique [0002] Oral diseases (oral ulcers, periodontitis, gingivitis, pericoronitis), throat diseases (acute and chronic pharyngitis, tonsillitis) are clinical common and frequently-occurring diseases. Iodine has been used as a disinfectant for more than a century. It has non-selective and efficient killing effects on various bacteria, fungi and viruses. The "iodine-containing throat tablet" that has been used most clinically for many years has not solved the stability problem of the preparation. The patent No. 90106682.6 invented cediiodine buccal tablet and its preparation method. The distribution ratio of each component in the inventive compound is as follows: 0.20-7.0% of cedi iodine; 0.1-1.0% of menthol; 0.5-3.0% of citric acid;...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K33/18A61K47/14A61K47/38A61P1/02A61P11/04
Inventor 王兴华汪红华胡红丰汤贤孙晏敏红吴兰燕
Owner 浙江华润三九众益制药有限公司