Medium chain fatty acid liposome and its prepn

A medium-chain fatty acid and fatty acid lipid technology, applied in the field of medium-chain fatty acid liposomes and their preparation, to achieve the effects of stable quality, uniform particle size and high bioavailability

Inactive Publication Date: 2007-08-22
NANCHANG UNIV
View PDF0 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report about medium-chain fatty acid liposomes. The medium-chain fatty acids are made into liposomes, which can be used as aerosol spray or injection, which improves the utilization of medium-chain fatty acids.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Weigh 0.4013g medium-chain fatty acid, 4.0310g soybean lecithin, 0.8020g cholesterol and 0.4008g Tween-80, dissolve in 100ml dichloromethane, place in a water bath at 38°C for vacuum rotary evaporation to remove dichloromethane, and make the mixture in eggplant type A uniform lipid film was formed in the flask, and 200 mL of phosphate buffer solution with pH 6.0 to 6.8 was added to hydrate and wash the film at 35°C for 1.5 hours, then sonicated for 15 minutes, and filtered to obtain milky white medium-chain fatty acid liposomes. The yield is 76.2%, the particle size is 268.3nm, and the Zeta potential is -50.78mV.

[0012] After the liposomes were stored at room temperature for 5 months, it was measured that the encapsulation efficiency of the medium-chain fatty acid liposomes was 70.8%, the particle size was 319.9 nm, and the Zeta potential was -51.23 mV.

Embodiment 2

[0014] Weigh 0.5100g medium-chain fatty acid, 4.010g hydrogenated soybean lecithin, 1.0502g cholesterol and 1.0018g deoxycholate, dissolve in 100ml methylene chloride, place in a water bath at 38°C for vacuum rotary evaporation to remove methylene chloride, and make the mixture in eggplant A uniform lipid film was formed in a type flask, and 250 ml of phosphate buffer solution of pH 6.0 to 6.8 was added to hydrate and wash the film at 35°C for 1.5 hours, then ultrasonicated for 15 minutes, and filtered to obtain milky white medium-chain fatty acid liposomes. The sealing rate is 76.4%, the particle size is 253.3nm, and the Zeta potential is -51.46mV.

[0015] After the above-mentioned medium-chain fatty acid liposomes were stored at room temperature for 5 months, it was measured that the encapsulation efficiency of the medium-chain fatty acid liposomes was 69.5%, the particle size was 264.7nm, and the Zeta potential was -52.34mV. Analysis of product characteristics

[0016] Th...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
Login to view more

Abstract

The present invention is medium chain fatty acid liposome and its preparation. The medium chain fatty acid liposome is prepared with medium chain fatty acid 1 weight portions, phospholipid 5-20 weight portions, cholesterol 1-8 weight portions, and surfactant 1-5 weight portions. The medium chain fatty acid liposome has the advantages of stable quality, small and homogeneous size, high bioavailability, and encapsulating rate over 70 %.

Description

technical field [0001] The invention relates to a medium-chain fatty acid liposome and a preparation method thereof. Background technique [0002] The most common definition of medium-carbon chain fatty acids is hexanoic acid (C6:0) with 6 carbon elements to lauric acid (dodecanoc; C12:0) with 12 carbon elements as the main components; from nutritional physiology, nutritional pharmacology The point of view is defined by fatty acid octanoic acid (C8:0) with 8 carbon elements and decanoic acid (C10:0) with 10 carbon elements. [0003] Medium-chain fatty acids have many unique physiological functions. Since their absorption process is mainly completed in the portal system, compared with long-chain fatty acids absorbed in the lymphatic system, they have the characteristics of fast absorption, no accumulation, and almost all of them are consumed as energy. . (1) Once MCFA enters the liver, it can be rapidly oxidized, C 8:0 and C 10:0 None need carnitine to help them cross the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/20A61K9/127A61K47/24A61P3/02
Inventor 刘成梅刘伟王瑞莲万婕涂宗财梁瑞红
Owner NANCHANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap