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Medium chain fatty acid liposome and its prepn

A medium-chain fatty acid and fatty acid lipid technology, applied in the field of medium-chain fatty acid liposomes and their preparation, to achieve the effects of stable quality, uniform particle size and high bioavailability

Inactive Publication Date: 2007-08-22
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report about medium-chain fatty acid liposomes. The medium-chain fatty acids are made into liposomes, which can be used as aerosol spray or injection, which improves the utilization of medium-chain fatty acids.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Weigh 0.4013g medium-chain fatty acid, 4.0310g soybean lecithin, 0.8020g cholesterol and 0.4008g Tween-80, dissolve in 100ml dichloromethane, place in a water bath at 38°C for vacuum rotary evaporation to remove dichloromethane, and make the mixture in eggplant type A uniform lipid film was formed in the flask, and 200 mL of phosphate buffer solution with pH 6.0 to 6.8 was added to hydrate and wash the film at 35°C for 1.5 hours, then sonicated for 15 minutes, and filtered to obtain milky white medium-chain fatty acid liposomes. The yield is 76.2%, the particle size is 268.3nm, and the Zeta potential is -50.78mV.

[0012] After the liposomes were stored at room temperature for 5 months, it was measured that the encapsulation efficiency of the medium-chain fatty acid liposomes was 70.8%, the particle size was 319.9 nm, and the Zeta potential was -51.23 mV.

Embodiment 2

[0014] Weigh 0.5100g medium-chain fatty acid, 4.010g hydrogenated soybean lecithin, 1.0502g cholesterol and 1.0018g deoxycholate, dissolve in 100ml methylene chloride, place in a water bath at 38°C for vacuum rotary evaporation to remove methylene chloride, and make the mixture in eggplant A uniform lipid film was formed in a type flask, and 250 ml of phosphate buffer solution of pH 6.0 to 6.8 was added to hydrate and wash the film at 35°C for 1.5 hours, then ultrasonicated for 15 minutes, and filtered to obtain milky white medium-chain fatty acid liposomes. The sealing rate is 76.4%, the particle size is 253.3nm, and the Zeta potential is -51.46mV.

[0015] After the above-mentioned medium-chain fatty acid liposomes were stored at room temperature for 5 months, it was measured that the encapsulation efficiency of the medium-chain fatty acid liposomes was 69.5%, the particle size was 264.7nm, and the Zeta potential was -52.34mV. Analysis of product characteristics

[0016] Th...

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PUM

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Abstract

The present invention is medium chain fatty acid liposome and its preparation. The medium chain fatty acid liposome is prepared with medium chain fatty acid 1 weight portions, phospholipid 5-20 weight portions, cholesterol 1-8 weight portions, and surfactant 1-5 weight portions. The medium chain fatty acid liposome has the advantages of stable quality, small and homogeneous size, high bioavailability, and encapsulating rate over 70 %.

Description

technical field [0001] The invention relates to a medium-chain fatty acid liposome and a preparation method thereof. Background technique [0002] The most common definition of medium-carbon chain fatty acids is hexanoic acid (C6:0) with 6 carbon elements to lauric acid (dodecanoc; C12:0) with 12 carbon elements as the main components; from nutritional physiology, nutritional pharmacology The point of view is defined by fatty acid octanoic acid (C8:0) with 8 carbon elements and decanoic acid (C10:0) with 10 carbon elements. [0003] Medium-chain fatty acids have many unique physiological functions. Since their absorption process is mainly completed in the portal system, compared with long-chain fatty acids absorbed in the lymphatic system, they have the characteristics of fast absorption, no accumulation, and almost all of them are consumed as energy. . (1) Once MCFA enters the liver, it can be rapidly oxidized, C 8:0 and C 10:0 None need carnitine to help them cross the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/20A61K9/127A61K47/24A61P3/02
Inventor 刘成梅刘伟王瑞莲万婕涂宗财梁瑞红
Owner NANCHANG UNIV
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