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Method of preparing oxygen supplying solution for improving economy tissue

An oxygen supply and solution technology, applied in the field of biomedicine, can solve the problems of high cost and lack of second-generation alternative products, and achieve the effects of good stability, uniform particle size distribution, and increased blood oxygen content and saturation

Inactive Publication Date: 2007-09-12
禹城科海生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the high cost and the lack of second-generation alternative products, Green Cross was forced to terminate the production of this product in 1994.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Mother liquor preparation

[0009] 1. Ingredients: 1000Kg distilled water, 9Kg perfluorotripropylamine, 1Kg perfluorodecalin, 0.01Kg phospholipid;

[0010] 2. Mixing emulsification: temperature control 15°C, pH value 7.26, tank pressure 600mmHg, stirring, ultrasonic vibration for 8 hours;

[0011] 3. Packing by filtration: the filter membrane has a pore size of 4 μm, sealed package, 1L per bottle, and stored at 2°C to 8°C. The whole process takes 12-14 hours in total.

Embodiment 2

[0013] Oral oxygen solution preparation

[0014] Raw material formula: mother liquor 1L, drinking water 1000L, dextran 0.5L, sodium salt 20g, potassium salt 1g;

[0015] Preparation Process:

[0016] Put the above raw materials into a sealed tank and shake and mix well; keep the pressure in the tank at 600mmHg at room temperature, and ultrasonically shake at 20KHz for 1 hour; filter with a filter with a pore size of 12μm; hours; sealed filling 135ml / bottle.

Embodiment 3

[0018] Oxygen solution preparation for intravenous infusion

[0019] Raw material formula: mother liquor 1L, normal saline 1000L, dextran 0.5L;

[0020] Preparation Process:

[0021] Put the above raw materials into a sealed tank and shake and mix well; keep the pressure in the tank at 600mmHg at room temperature, and ultrasonically shake at 20KHz for 1 hour; filter with a filter with a pore size of 0.3μm; 1 hour; sealed filling 125ml / bag.

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PUM

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Abstract

The process of preparing solution for improving oxygen supply of organism tissue belongs to the field of biomedicine technology. The mother liquid is emulsified perfluoro carbon compound in the granularity of 0.1-0.3 microns. The mother liquid is prepared with the materials including perfluoro triethylamine, perfluoro tripropylamine, perfluoro tributylamine, perfluoro decalin, perfluoro adamantane, phospholipid, distilled water, etc, and through compounding, mixing, emulsifying, filtering and packing. The mother liquid is added with dextran, sodium salt, potassium salt, liver growth factor and other supplementary material based on different uses to prepare different types of oxygen supply solution for oral taking, venoclysis, gastrointestinal perfusing or external use. The oxygen supply solution may be used in treating various diseases caused by anoxia.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a method for preparing an emulsion for improving oxygen supply to body tissues. Background technique [0002] The prior art and product similar to the present invention are the temporary blood substitute Fluosol for injection produced by the Japanese Green Cross Company nearly 20 years ago.  . Fluosol  It is composed of 14% w / v perfluorodecalin and 6% w / v perfluorotripropylamine, emulsified by synthetic poloxamer, Pluronic F-68. The main disadvantage of its technical products is that the preparation process is complex, requiring ten processes such as mixing, stirring, and static reaction. One production cycle takes 5 working days, and the output is small, so the price is expensive. The product needs to be thawed and mixed before use, and the ingredients of the mixed product are unstable, with a stability period of only 8 hours, can only be used for intravenou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/00A61K9/107A61K47/18A61P43/00
Inventor 陈福海陈祥海赵鹏陈汉超
Owner 禹城科海生物工程有限公司
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