Method for controlling the quality of schisandra raw material fingerprint in the plant medicine for improving hemorheology

A quality control method and fingerprint technology, which are applied in the field of raw material quality control of Schisandra chinensis, can solve the problems of lack of quality control of traditional Chinese medicinal materials and imperfection, and achieve the effects of reliable method, strong specificity and stable medicinal quality.

Active Publication Date: 2007-09-26
SHANGHAI MODERN CHINESE TRADITIONAL MEDICINE TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0019] There are also some research reports on the fingerprints of Schisandra medicinal materials, but they are

Method used

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  • Method for controlling the quality of schisandra raw material fingerprint in the plant medicine for improving hemorheology
  • Method for controlling the quality of schisandra raw material fingerprint in the plant medicine for improving hemorheology
  • Method for controlling the quality of schisandra raw material fingerprint in the plant medicine for improving hemorheology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Schisandra Medicinal Material: Northeast China (10 batches)

[0066] equipment name

model

production unit

Electronic balance

AL104

METTLER TOLEDO

High performance liquid chromatography

Agilent 1100series

Agilent

Column

Luna C 18 250×4.6cm

temperate box

TC-100

T&D

Circulating water multi-purpose vacuum pump

(Rotary evaporator)

SHZ-D(3)

Gongyi Yuhua Instrument Co., Ltd.

ultrasonic cleaner

KQ-50E

Kunshan Ultrasonic Instrument Co., Ltd.

[0067] Weigh 0.5g schisandra medicinal material powder, add 20ml 80% methanol, weigh, ultrasonically extract for 50min, make up the lost weight, and filter through 0.45μm microporous membrane to obtain the test solution. Chromatographic conditions: column temperature: 35°C, detection wavelength: 254nm, injection volume: 20μl, chromatographic column: Eclipse (150×4.6mm, 5μm), elution conditions (see Table 1)

[...

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PUM

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Abstract

The invention relates to a schisandra fruit fingerprint spectrum quality control method, comprising that (1), adding 0.5g schisandra fruit to extract via microwave for 50min, filtering, (2), washing flow phase gradient that the spectrum column is Eclipse, as 0-40min, 60-20% A, 40-80% B, flow speed is 0.8-1.2ml/min, the wavelength is 210-280nm, the column temperature is 20-40Deg. C, and the sample amount is 10-20ul, (3), building standard fingerprint spectrum that the first peak is schisandra fruit alcohol 1, the third peak is schisandra fruit alcohol 2, the fourth peak is gemixin N/ isomer, the sixth peak is schisandra fruit I element, the seventh and eighth peaks are gemixin N/ isomer, the ninth peak is schisandra fruit II element, (4), controlling the quality of fingerprint spectrum that the check peak relative holding times are 1.00, 1.25, 1.63, 1.88, 3.18 and 3.27, (5), the schisandra fruit planting collecting method. The invention can control the quality of materials to assure the stable quality of product.

Description

technical field [0001] The invention belongs to the field of quality control methods for raw materials of Schisandra chinensis, in particular to a method for quality control of fingerprints of raw materials of Schisandra chinensis in herbal medicines for strengthening health and removing blood stasis. Background technique [0002] Fructus Schisandrae chinensis is the dry and mature fruit of Schisandra chinensis (Turcz.) Baill., a plant of the genus Schisandra in the family Magnoliaceae. Schisandra, also known as black plum, mountain pepper, and jujube, is named for its five flavors of sweet, sour, pungent, bitter, and salty. It was first recorded in "Shen Nong's Materia Medica" and listed as top grade. There are also records. [0003] "Flora of China" describes Schisandra chinensis as a deciduous woody vine, glabrous except for the pilose on the back of the young leaves and the ciliate bud scales. Flowers are mostly unisexual, solitary or clustered in leaf axils, male flow...

Claims

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Application Information

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IPC IPC(8): A61K36/57G01N30/02G01N30/86A61K131/00
Inventor 胡坪潘一峰
Owner SHANGHAI MODERN CHINESE TRADITIONAL MEDICINE TECH DEV
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