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Substituted piperidines as modulators of dopamine neurotransmission

A free, compound technology for neurological diseases, metabolic diseases, organic chemistry, etc.

Inactive Publication Date: 2010-12-15
NSAB FILIAL AF NEUROSEARCH SVERIGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Furthermore, neither of the two patent applications discloses 2,3-substitution of aryl rings, and alternative substitution patterns (such as 3,4-disubstitution with halogen at the 4-position) or mono The substitution (3-position) did not result in a compound with the same efficacy as the 2,3-disubstitution disclosed in the present invention

Method used

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  • Substituted piperidines as modulators of dopamine neurotransmission
  • Substituted piperidines as modulators of dopamine neurotransmission
  • Substituted piperidines as modulators of dopamine neurotransmission

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Embodiment 1

Embodiment 2

Embodiment 3

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Abstract

The present invention relates to compounds having therapeutic effects against disorders in the central nervous system, and in particular substituted hydroxypiperidines of the formula 1: wherein R1, R2, and R3 are as defined herein.

Description

field of invention The present invention relates to novel modulators of dopamine neurotransmission, and more particularly, the present invention relates to novel substituted piperidines and their use. Background of the invention Dopamine is a neurotransmitter in the brain. Since this discovery, made in the 1950s, the function of dopamine in the brain has been intensively studied. To date, it is well established that dopamine is essential in several aspects of brain function, including motor, cognitive, sensory, affective, and autonomic functions (eg, appetite regulation, body temperature, sleep). Therefore, modulation of dopaminergic function may be beneficial in the treatment of a wide range of disorders affecting brain function. Indeed, drugs that act directly or indirectly on central dopamine receptors are commonly used to treat neurological and psychiatric disorders such as Parkinson's disease and schizophrenia. However, currently available dopaminergic drugs can have...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D211/52A61P25/00A61K31/445C07D
CPCC07D211/52A61P3/04A61P15/00A61P25/00A61P25/06A61P25/14A61P25/16A61P25/18A61P25/22A61P25/24A61P25/28A61P25/30
Inventor C·索内松L·斯万松N·瓦特斯
Owner NSAB FILIAL AF NEUROSEARCH SVERIGE