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Compound traditional Chinese medicinal preparation for treating chronic laryngopharyngitis and its preparation method

A technology for chronic pharyngitis and compound traditional Chinese medicine, which is applied in the directions of medical preparations, drug combinations, and pharmaceutical formulations containing active ingredients, can solve the problems of insufficient applicable population, narrow antibacterial spectrum, weak antibacterial power, etc., and achieves remarkable curative effect, Broad antibacterial spectrum and enhanced antibacterial effect

Inactive Publication Date: 2008-01-09
CHENGDU LIST PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Patent applications with application numbers 03129199.6 and 200510075384.4 respectively disclosed the application of single herb Atractylodes macrocephala and single herb rabbit ear wind in the treatment of pharyngitis. However, single medicines often have the disadvantages of narrow antibacterial spectrum, weak antibacterial power, and insufficient application to a wide range of people. , so far, there is no report on the compound preparation of rabbit ear wind and Baizhu used in the treatment of chronic pharyngitis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take 2500g of Xingxiang Rabbit’s Ear Wind and 1000g of Atractylodes Rhizoma Atractylodes Rhizome, wash and crush them, add 8 to 10 times the amount of water for the first time, soak for 30 minutes, heat and decoct for 2.5 hours, filter, and collect the filtrate; add 6 times the amount of water for the second time water, decocted for 2 hours, filtered, collected the filtrate, combined the filtrate decocted twice, concentrated under reduced pressure to a clear paste with a relative density of 1.06 (60°C), let it cool, added ethanol to make the alcohol content 75%, and statically Place it for 24 hours, take the supernatant, wash the precipitate twice with 75% ethanol, combine the washing liquid with the supernatant, recover the ethanol and concentrate it into a thick paste with a relative density of 1.36 (60° C.).

[0016] Take 1 part of the above-mentioned thick paste, add 2 parts of sucrose, 1 part of dextrin, and an appropriate amount of ethanol, make granules, dry, and ...

Embodiment 2

[0018] Take 2500g of Xingxiang Rabbit’s Ear Wind and 1000g of Atractylodes Rhizoma Atractylodes Rhizome, wash and crush them, add 8 to 10 times the amount of water for the first time, soak for 30 minutes, heat and decoct for 2.5 hours, filter, and collect the filtrate; add 6 times the amount of water for the second time water, decocted for 2 hours, filtered, collected the filtrate, combined the filtrate decocted twice, concentrated under reduced pressure to a clear paste with a relative density of 1.06 (60°C), let it cool, added ethanol to make the alcohol content 75%, and statically Place it for 24 hours, take the supernatant, wash the precipitate twice with 75% ethanol, combine the washing liquid with the supernatant, recover the ethanol and concentrate it into a thick paste with a relative density of 1.36 (60° C.).

[0019] Add 1000ml of water and 0.5g of benzoic acid to the thick paste prepared above, filter, and divide into spray bottles, 10ml per bottle, to obtain a spray...

Embodiment 3

[0021] Experimental Study on Effects of Compound Tuerfeng Capsules on Rabbit Chronic Pharyngitis Model Induced by Ammonia and Turpentine

[0022] 1. Materials and methods

[0023] 1.1 Experimental materials

[0024] 1.1.1 Rabbits and feeding conditions

[0025] Seventy 3-month-old Japanese big-eared white rabbits, half male and half male, weighing 2.00kg±0.21kg, were fed with full-price pellet feed after quarantine, and cleaned regularly every day.

[0026] 1.1.2 Drugs

[0027] Compound Rabbit Erfeng Capsules: The clinical daily dose for adults is equivalent to 36g of raw medicinal materials, administered 3 times a day, 12g each time, equivalent to 0.6g / kg.d of raw medicinal materials (average adult body weight is 60kg). During the experiment, the low dose, medium dose and high dose were in order: 1.8g / kg.d, 3.6g / kg.d, 5.4g / kg.d were 3, 6 and 9 times of clinical daily dose respectively. During the experiment, the same pharmaceutical preparation was used for multiple admini...

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Abstract

The present invention relates to a compound Chinese medicine preparation for effectively curing chronic laryngopharyngitis. Said compound Chinese medicine preparation can be made up by using 2500g of Chinese medicinal material gerbera piloselloides and 1000g of ovate atractylodes root through a certain preparation process. Said compound Chinese medicine preparation can be made into granules preparation, capsule preparation or spray preparation, etc. Said invention also provides the concrete steps of said preparation process.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation for treating chronic pharyngitis and a preparation method thereof, in particular to a compound Chinese medicine preparation containing rabbit ear wind and Atractylodes macrocephala extract and a preparation method thereof. Background technique [0002] Chronic pharyngitis is mostly caused by recurrent acute pharyngitis, which belongs to chronic inflammation of throat mucosa, submucosa and lymphoid tissue. The pathological features mainly show that the pharyngeal mucosa is congested, dark red or slightly edematous, and there may be scattered small lymphoid follicles surrounded by dilated vascular networks or covered with transparent mucus. Common symptoms are throat discomfort, foreign body sensation, sometimes slight pain and dryness, manifested as throat clearing, irritating dry cough, difficulty speaking or hoarseness. Western medicine treatment is mainly based on antibacterial and ...

Claims

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Application Information

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IPC IPC(8): A61K36/284A61K9/12A61K9/16A61K9/48A61P11/04
Inventor 赵力科
Owner CHENGDU LIST PHARMA
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