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Segmented intestine targeted preparation of orgotein polypeptide and method of preparing the same

A technology of colon targeting and liver protein, which is applied in the direction of peptide/protein components, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as unseen research reports, and achieve inhibition of virus replication, Restoring the function of liver cells and reducing the effect of jaundice

Inactive Publication Date: 2008-02-27
李立
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no colon-targeting preparation of liver protein polypepti

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0029] Example 1

[0030] Weigh the spare 20 grams of hepatic protein peptide freeze-dried powder, 10 grams of oxymatrine raw materials and 0.2 grams of vitamin B, mix them into a compound powder, place them in a centrifugal coating granulator, and then spray 50% sucrose syrup to moisten it. Air-dried at 40~70℃ for 4 hours to prepare 60~80 mesh pellet core. With 3% povidone K30 ethanol solution as the binder, the powder feeder is sprayed to the pellet core to enlarge the pellet core to The pellets of 500-800μm are dried and sieved to obtain medicated pellets. The weight percentage of each component is controlled as follows: compound powder 60%, sucrose 25%, and povidone K3015%.

[0031] Weigh 60 grams of acrylic resin S100, add it to 800 ml of 80% ethanol solution, stir to dissolve, then add 7 grams of triethyl citrate and 12 grams of talc in turn, stir and mix, and pass the resulting solution through an 80 mesh steel sieve Then, the pH-dependent colon-targeting coating solution i...

Example Embodiment

[0033] Example 2

[0034] Weigh the spare 25 grams of hepatic protein peptide freeze-dried powder, 4 grams of matrine raw materials, 1.2 grams of vitamin B, and mix them into a compound powder, place them in a centrifugal coating granulator, and spray 50% sucrose syrup to moisten it. Air-dried at 40~70℃ for 4 hours to prepare 60~80 mesh pellet core. With 3% povidone K30 ethanol solution as the binder, the powder feeder is sprayed to the pellet core to enlarge the pellet core to The 100-500μm pellets are dried and sieved to obtain medicated pellets. The weight percentage of each component is controlled as follows: 92% compound powder, 5% sucrose, and povidone K303%.

[0035] Weigh 60 grams of acrylic resin, in which the weight ratio of acrylic resin S100 and acrylic resin L100 is 1:1.5, add it to 800 ml of 80% ethanol solution, stir to dissolve, and then add 11 g of triethyl citrate and 4 g of talc in sequence Powder, stir and mix well, and pass the obtained solution through an 80-...

Example Embodiment

[0037] Example 3

[0038] Weigh the spare 160 grams of hepatic protein peptide freeze-dried powder and 160 grams of licorice extract, pulverize and mix them into a compound powder, place it in a centrifugal coating granulator, and then spray with 50% sucrose syrup to moisten, and blow at 40~70℃ Dry for 4 hours to obtain 60-80 mesh pellet cores, using 3% povidone K30 ethanol solution as a binder, spray powder from the powder feeder to the pellet core to increase the pellet core to 800-1000μm pellets , Dried and sieved to obtain medicated pellets. The weight percentage of each component is controlled as follows: compound powder 80%, sucrose 15%, and povidone K305%.

[0039] Weigh 600 grams of acrylic resin, in which the weight ratio of acrylic resin S100 and acrylic resin L100 is 1:1.5, add to 10000 ml of 80% ethanol solution, stir to dissolve, and then add 70 grams of triethyl citrate and 120 grams of talc in sequence Powder, stir and mix, and the resulting solution is passed throu...

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Abstract

The invention provides a colon specific targeting preparation of orgotein polypeptides and its preparing process, wherein the preparation is prepared through coating the drug-containing micro-pellets containing myocardial protein polypeptides components with colon targeting coating liquid, or directly loading the drug-containing micro-pellets into the shells of the colon targeting capsule. The preparation provided by the invention can make the colon release drugs enter blood circulation through colon, thereby avoiding metabolism destruction of the conventional oral preparation peptides drugs on the stomach, as a result, the therapeutic action of the drugs can be sufficiently exploited.

Description

technical field [0001] The invention relates to a colon-targeting preparation, in particular to a colon-targeting preparation of liver protein polypeptide for treating various types of hepatitis including viral hepatitis and liver cirrhosis and a preparation method thereof. Background technique [0002] Studies have shown that hepatitis patients and hepatitis virus carriers account for more than 10% of the total population in my country at present, and hepatitis has become one of the diseases that seriously threaten the health of our people. Hepatic protein polypeptide is an effective ingredient in the treatment of such diseases. Hepatic protein polypeptide is a small molecular polypeptide that can promote liver cell regeneration and restore liver cell function. It has a good therapeutic effect on various types of hepatitis, can enhance the immune function of the body, reduce transaminase, subside jaundice, inhibit virus replication, and has no obvious adverse reactions. ...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61K38/21A61K38/22A61K9/48A61K9/16A61K47/34A61K47/38A61P1/16A61P31/14A61P31/20A61K31/047A61K31/07A61K31/195A61K31/355A61K31/357A61K31/375A61K31/4168A61K31/4375A61K31/522A61K31/714A61K31/513A61K31/519A61K31/59A61K31/704A61K31/7068A61K33/06A61K33/28A61K35/56A61K35/64A61K36/752A61K35/618A61K35/644A61K47/32
Inventor 李立吕应年李延平
Owner 李立
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