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Application of forsythiaside in the preparation of medicament for treating or preventing acute and chronic liver damnification and liver fibrosis

A technology for forsythiaside and liver fibrosis, which is applied in the directions of drug delivery, drug combination, digestive system, etc., can solve the problems of unsatisfactory treatment effect, high cost, and inaccurate drug efficacy.

Inactive Publication Date: 2010-10-20
SHANDONG LUYE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Interferon is the drug of choice, but there are disadvantages such as large dosage, high cost, high toxicity and side effects, low effective rate, and easy recurrence after drug withdrawal.
The therapeutic effect of traditional Chinese medicine is also unsatisfactory. The curative effect of the medicine is inaccurate, the treatment period is long, and the cost is high. Long-term use will cause side effects and damage the health of the body.

Method used

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  • Application of forsythiaside in the preparation of medicament for treating or preventing acute and chronic liver damnification and liver fibrosis
  • Application of forsythiaside in the preparation of medicament for treating or preventing acute and chronic liver damnification and liver fibrosis
  • Application of forsythiaside in the preparation of medicament for treating or preventing acute and chronic liver damnification and liver fibrosis

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0014] Preparation Example 1 Preparation of forsythiaside

[0015] Take 5Kg of Forsythia fruit, crush it to pass a No. 3 sieve, add 50% ethanol to extract twice at room temperature, use 20 times ethanol solution for the first time, soak for 4 hours, add 10 times ethanol solution for the second time, soak at room temperature for 3 hour. Combine the two extracts, adjust the pH to about 4, de-alcoholize at low temperature and reduced pressure, load the NK-9 type macroporous resin column, wash 3 column volumes with water, then wash 5 column volumes with 10% ethanol aqueous solution, and then use 40% ethanol eluted 5 column volumes. The 40% alcohol elution effluent was collected and dried under reduced pressure at 70°C to obtain 21.2 g of forsythiaside with a content of 90.4%.

preparation example 2

[0016] Preparation Example 2 Preparation of forsythiaside

[0017] Take 1Kg of Forsythia leaves, pulverize and add 50% ethanol to extract twice at room temperature, the first time with 20 times the amount of ethanol solution, soak for 4 hours, the second time with 10 times the amount of ethanol solution, soak at room temperature for 3 hours. Combine the two extracts, adjust the pH to about 4, dealcoholize under reduced pressure at low temperature, and load the polyamide resin column. First wash 3 column volumes with water, then wash 5 column volumes with 25% ethanol aqueous solution, and then wash with 40% ethanol Take off 5 column volumes. The 40% alcohol elution effluent was collected, concentrated under reduced pressure at 70°C, placed at low temperature for two days, centrifuged, and the precipitate was dried to obtain 36.8 g of forsythiaside with a content of 95.1%.

preparation example 3

[0018] Preparation Example 3 Preparation of forsythiaside lyophilized powder injection

[0019] Take 20.0g of forsythiaside, add 2000ml of water for injection to dissolve it, add 8g of mannitol, stir to dissolve, ultrafiltration to obtain a pyrogen-free clear liquid, pour it into a 10ml vial, 2ml / piece, press freeze-dried powder The needle process is freeze-dried, and each freeze-dried powder injection containing 20.0 mg of forsythiaside is made.

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Abstract

The present invention is the application of forsythia ester glycoside in preparing medicine for preventing and treating acute and chronic liver injury and liver fibrosis. The dosage of the medicine is 25-800 mg for injection and 50-1500 mg for orally taken preparations. The medicine with forsythia ester glycoside as effective component may be prepared into injection, tablet, capsule, pill or other forms, preferably freeze dried powder for injection and capsule.

Description

Technical field [0001] The invention relates to a medicine for the treatment of liver diseases, in particular to the application of forsythiaside in the prevention or treatment of acute and chronic liver injury and liver fibrosis caused by viruses, chemicals and medicines. Background technique [0002] Hepatitis refers to inflammation of the liver. Many pathogenic microorganisms such as viruses, bacteria, fungi, rickettsiae, spirochetes and certain protozoa and parasites can cause liver inflammation; various poisons (such as arsenic), toxins (bacterial endotoxins), chemical substances ( Ethanol, etc.) and certain drugs (such as remifen, indomethacin, chlorpromazine, etc.) poisoning can cause toxic hepatitis. Hepatitis caused by drug poisoning is called drug-induced hepatitis; hepatitis caused by chemical substances is called chemical hepatitis; hepatitis caused by virus is called viral hepatitis, which includes various types of hepatitis virus, herpes virus, Epstein-Barr virus, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7028A61K9/00A61P1/16
Inventor 蒋王林曲桂武田京伟
Owner SHANDONG LUYE PHARMA CO LTD
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