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Helicid powder injection for intravenous drip and preparation method

A technology of tofu fruit glycoside powder injection and tofu fruit glucoside powder, which is applied in the field of drug intravenous injection preparations and its preparation, and can solve the problems of not using intravenous administration routes, etc.

Inactive Publication Date: 2008-04-23
YUNNAN BAIYAO GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This kind of injection is a small injection, which is limited to intramuscular injection. It highlights the anti-inflammatory and analgesic effects of tofu fruit glycosides, but it is not used as an intravenous injection drug, and no intravenous administration route is used.

Method used

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  • Helicid powder injection for intravenous drip and preparation method
  • Helicid powder injection for intravenous drip and preparation method
  • Helicid powder injection for intravenous drip and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Tofu glucoside powder injection (1000 sticks):

[0042] Tofu fruit glycosides 100g

[0043] Mannitol 100g

[0044] Preparation Process:

[0045] In a sterile environment, first dissolve mannitol in 15,000ml of water for injection at 70°C, then add 100g of tofu glucoside, and pay attention to make it completely dissolved, add water for injection to 2,000ml, and adjust the pH to 6.0. Keep warm and filter, and the filtrate is filtered through filter paper and a filter membrane below 0.4 μm. The fine filtrate is sent to the subpackaging machine, divided into 20ml per tube, freeze-dried, covered with a rubber stopper, and tied with a cover, so that 1000 tubes can be produced with a specification of 100 mg per tube.

Embodiment 2

[0047] According to the following formula, and using the preparation method of Example 1, 1000 sticks of bean curd glucoside powder injection finished products with a specification of 150 mg / bottle can be obtained.

[0048] Tofu fruit glycosides 150g

[0049] Mannitol 95g

[0050] Glycine 5g

Embodiment 3

[0052] According to the following formula, and using the preparation method of Example 1, 1000 sticks of tofu fruit glycoside powder injection finished product with a specification of 200mg / pin can be obtained.

[0053] Tofu fruit glycosides 200g

[0054] Glucose 140g

[0055] Sodium chloride 30g

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PUM

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Abstract

The present invention relates to a medicine intravenous injection preparation and its preparation method. The helicid powder injection preparation described by said invention for intravenous drop-injection is formed from (by wt%) 30-99.9% of helicid and 0.1-70% of water soluble medicinal auxiliary material. Said invention can be mainly used for curing neurasthenic syndrome, angioneuralgia, sudden deafness, vestibular neuronitis, vertebrobasilar ischemia and post-traumatic brain syndrome, etc. Specially it can obtain obvious therapeutic effect for curing vertiginous diseases, such as Meniere's disease, drug-induced vertigo and traumatic vertigo, etc.

Description

technical field [0001] The invention relates to a drug intravenous injection preparation and a preparation method thereof. Background technique [0002] Tofu fruit glycosides (Hilieidum), also known as Kunming shenshuaiguosu, shenshuaiguosu, etc., is a natural plant monomer component extracted from the fruit of Yunnan Jingpo medicine Muza (Helicia erratica Hock.F). The Shenshuaiguosu Tablet made from it has been clinically used for more than 20 years and is currently the main drug used for calming and sedating. Due to the poor water solubility of tofu fruit glycosides, and the current dosage is also small, oral preparations have poor drug absorption, slow effect enhancement, and low bioavailability, resulting in a mismatch between its curative effect and its activity. [0003] Chinese patent application CN03117668.2 discloses a "tofu glucoside powder injection and its preparation method", which is characterized in that each powder injection contains 25-600 mg tofu glucoside...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61K9/14A61K47/40A61K47/34A61K47/36A61K47/24A61K47/16A61K47/10A61K47/02A61P29/00A61K47/18A61K47/26
Inventor 王真万近福林怡张立群
Owner YUNNAN BAIYAO GROUP
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