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Venous injection powder injection for preventing and treating ischemic cerebral apoplexy and preparation method thereof

A technology of ischemic stroke and powder injection, which is applied in chemical instruments and methods, preparation of sugar derivatives, medical preparations containing active ingredients, etc., can solve the problems of unaffordable long-term treatment costs, easy recurrence, poor curative effect, etc. question

Inactive Publication Date: 2008-04-30
杨泗兴
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, a variety of traditional Chinese medicines for the treatment of cerebral apoplexy have come out one after another. The medicines on the domestic market such as: Naodesheng Tablets, Buchang Naoxintong, Di'ao Xinxuekang, Shuluo Qingnao Tablets, Twenty-five Flavor Pearl Pills, Seventy Weizhuzhu Pills, Zaizao Pills, Compound Danshen Injection, Acanthopanax Injection, Xuesaitong, Qingkailing, Shenfu Injection, etc. have been clinically proven to have poor curative effects and require other drugs for auxiliary treatment and cure. Low rate, long course of treatment, even life-long medication, heavy burden, easy relapse, patients easily lose confidence in treatment, and common families cannot afford the cost of long-term treatment, etc.

Method used

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  • Venous injection powder injection for preventing and treating ischemic cerebral apoplexy and preparation method thereof
  • Venous injection powder injection for preventing and treating ischemic cerebral apoplexy and preparation method thereof
  • Venous injection powder injection for preventing and treating ischemic cerebral apoplexy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0115] Scrophulariaceae phenylpropanoid glycosides extract calculated as angoroside C 15g

[0116] Sodium chloride 80g

[0117] Take Radix Ginseng 40% ethanol and reflux extract once, add 5 times of ethanol each time to extract for 1 hour, recover ethanol, concentrate, add ethanol until the alcohol content reaches 60%, let sink for 24 hours, filter, recover ethanol, concentrate , add 4 times the amount of water, let it sink for 24 hours, filter, then apply weak polar macroporous resin D101, wash with water until clear, elute with 3 times the volume of 10% ethanol, and then elute with 4 times the volume of 50% ethanol , collect the eluent, concentrate, add 4 times the amount of water to the concentrated solution, precipitate for 24 hours, filter, concentrate under reduced pressure, and dry into a fine powder. Take 15 g of scrophulariaceae phenylpropanoid glycosides extract as angoroside C, Then add the amount of sodium chloride, add water for injection and stir to dissolve, us...

Embodiment 2

[0119] Scrophulariaceae phenylpropanoid glycosides extract calculated as angoroside C 85g

[0120] Mannitol 5g

[0121] Take Radix Ginseng with 80% ethanol and reflux extraction for 3 times, add 10 times of ethanol for extraction for 3 hours each time, recover ethanol, concentrate, add ethanol until the alcohol content reaches 85%, let sink for 72 hours, filter, recover ethanol, concentrate , add 6 times the amount of water, let it sink for 72 hours, filter, then apply the weak polar macroporous resin AB-8, wash with water until clear, elute with 10 times the volume of 40% ethanol, and then use 10 times the volume of 80% ethanol Elution, collect the eluent, concentrate, add 4-6 times the amount of water to the concentrated solution, settle for 24-72 hours, filter, concentrate, dry, and take 85g of scrophulariaceae phenylpropanoid glycosides extract (calculated as angoroside C) , then add the amount of mannitol, add an appropriate amount of water for injection and stir to diss...

Embodiment 3

[0123] Scrophulariaceae phenylpropanoid glycosides extract calculated as angoroside C 30g

[0124] Sorbitol 65g

[0125] Take Radix Ginseng 60% ethanol and reflux extract twice, each time add 8 times of ethanol to extract for 2 hours, recover ethanol, concentrate, add ethanol until the alcohol content reaches 75%, let sink for 48 hours, filter, recover ethanol, concentrate , add 5 times the amount of water, let it sink for 48 hours, filter, then apply the weak polar macroporous resin HPD450, wash with water until clear, elute with 6 times the volume of 30% ethanol, and then elute with 8 times the volume of 70% ethanol , collect the eluate, concentrate, add 5 times the amount of water to the concentrated solution, sink for 48 hours, filter, concentrate, and dry, get 30 g of scrophulariaceae phenylpropanoid glycosides extract in terms of angoloside C, and 60 g of sorbitol, Add an appropriate amount of water for injection and stir to dissolve, use 1mol / L hydrochloric acid and 1m...

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Abstract

The invention discloses an intravenous powder injection used for preventing and curing ischemic cerebral apoplexy and a process for preparation, which is made from phenolpropanoid glycosides extracted form radix scrophulariae, wherein the content of angolamycin glycosides C arrives to 100-850mg / g. The pharmacological research indicates that the invention brings significant effects in curing ischemic cerebral apoplexy.

Description

technical field [0001] The invention relates to a medicine for preventing and treating ischemic cerebral apoplexy, in particular to a Chinese patent medicine prepared from Chinese medicinal materials, and also relates to a preparation method of the medicine. Background technique [0002] Cerebrovascular disease is one of the important chronic diseases that endanger human health in the world today, and it is also one of the three major causes of global population death. According to the data released by the World Health Organization in 1979, among the 57 countries in the world, 40 countries rank among the top three in terms of death from stroke. In 1995, my country's statistical data showed that: stroke ranks first in urban areas and second in rural areas. It is estimated that there are currently 5 to 6 million stroke patients, and 3 / 4 of the survivors have varying degrees of disability [4] . Due to the acute onset, high mortality rate and high disability rate of stroke, i...

Claims

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Application Information

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IPC IPC(8): A61K31/7028A61K36/808A61K9/14A61P9/10C07H1/08A61K125/00
Inventor 杨泗兴
Owner 杨泗兴
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