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Total panax notoginsenosides, preparing method thereof, preparations thereof and applications thereof

A technology of Panax notoginseng saponins and preparations, applied in the field of Panax notoginseng saponins and their preparation, can solve the problems of cerebral ischemia, which have not been reported, and achieve the improvement of neurobehavioral disorders, treatment of ischemic cerebrovascular diseases, and reduction of cerebral ischemia. The effect of cerebral infarct size

Inactive Publication Date: 2014-06-25
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is no report on the role of Panax notoginseng saponins in the prevention and / or treatment of cerebral ischemia

Method used

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  • Total panax notoginsenosides, preparing method thereof, preparations thereof and applications thereof
  • Total panax notoginsenosides, preparing method thereof, preparations thereof and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0019] The preparation method of Panax notoginseng saponins of the present invention comprises the steps of raw material processing, reflux extraction, and filtration concentration, specifically:

[0020] A, raw material processing: the raw material Radix Notoginseng is pulverized into coarse powder;

[0021] B. Reflux extraction: add 60-80% ethanol with a weight ratio of 8-12 times, and reflux extraction for 2-4 times, each time for 1-2h;

[0022] C. Filtration, concentration and drying: coarse filtration after each extraction, combining the crude filtrates, and then performing fine filtration; the fine filtrates are concentrated to a relative density of 1.3-1.5 to obtain the total saponins of Panax notoginseng.

Embodiment approach

[0024] The coarse powder described in step A is 20~80 orders.

[0025] The amount of ethanol added in the B step is 70% ethanol with a weight ratio of 10 times.

[0026] The reflux extraction described in step B was performed 3 times, each time for 1.5h.

[0027] The fine filtration described in step C is membrane filtration, and the pore size of the filter membrane is 0.1-10 μm; the concentration described is atmospheric concentration or reduced pressure concentration, and the concentration is carried out by methods such as freeze-drying, thin-film concentration or spray-drying.

[0028] The total notoginseng saponins of the present invention are prepared into powders, or the total notoginseng saponins are added with pharmaceutically acceptable adjuvants to prepare granules, capsules, tablets, pills, oral liquids or injections.

[0029] The adjuvant includes conventional fillers, diluents, binders, excipients, absorption promoters, fillers, surfactants and stabilizers in the...

Embodiment 1

[0032] Grind the raw material Panax notoginseng into 20-mesh coarse powder, take 10 kg of coarse powder, add 80 kg of 60% ethanol to it; reflux extraction twice, each time for 1 hour; after each extraction, use a strainer to filter coarsely, and combine the coarse filtrate; The fine filtration of the membrane, the obtained fine filtrate is concentrated to 1.3 by the normal pressure drying method under normal pressure conditions, and concentrated to a relative specific density of 1.3, that is, to obtain the total saponins of notoginseng.

[0033] It was determined that the weight ratio of ginsenoside Rg1 to ginsenoside Rb1 in the prepared Panax notoginseng saponins was 1:0.9.

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PUM

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Abstract

The invention discloses total panax notoginsenosides, a preparing method thereof, preparations thereof and applications thereof. The total panax notoginsenosides comprise a ginsenoside Rg 1 and a ginsenoside Rb 1, with the weight ratio of the ginsenoside Rg 1 to the ginsenoside Rb 1 being 1:0.9-1.1. The preparing method includes smashing a raw material pseudo-ginseng into coarse powder, adding 8-12 times by weight of ethanol having a concentration of 60-80%, performing reflux extraction for 2-4 times for 1-2 h in each time, performing rough filtration after each extraction step, combining the filtrates of rough filtration, performing refined filtration, concentrating the filtrate of the refined filtration until the specific density is 1.3-1.5, thus obtaining the total panax notoginsenosides. The total panax notoginsenosides can be prepared into granules, capsules, tablets, pills, oral liquids and injections. The applications relate to applications of the total panax notoginsenosides in preparation of medicines used for preventing and / or treating ischemic cerebrovascular disease. The weight ratio of the ginsenoside Rg 1 to the ginsenoside Rb 1 is controlled to be within the range of 1:0.9-1.1. The total panax notoginsenosides can reduce the area of cerebral infarction caused by cerebellar ischemia / reperfusion and can improve neurobehavioral disturbances caused by the cerebral ischemia / reperfusion.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine extracts, and in particular relates to a kind of Panax notoginseng saponins and its preparation method, preparation and application. Background technique [0002] Ischemic cerebrovascular disease refers to cerebral vasospasm, cerebral insufficiency, cerebral thrombosis, cerebral embolism and other diseases caused by various reasons, resulting in cerebrovascular dysfunction, especially cerebrovascular blockage. Cerebral ischemia can cause loss of ion balance, excessive release of excitatory amino acids, increased oxidative stress, apoptosis and ultimately brain tissue necrosis. The disease has high morbidity, disability and mortality in real life, and has become one of the diseases that seriously endanger human health. [0003] Panax notoginseng is a plant of Araliaceae, also known as Tianqi, Sanqi, Jinbuhuan, blood ginseng, Sanqi and so on. Warm in nature, sweet in taste, sl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P9/10A61P25/00
Inventor 白洁杨兆祥曾宪思普俊学周小爽龚云麒罗富城
Owner KPC PHARM INC
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