Pharmaceutical composition of chicken bile and preparation thereof

The technology of a composition and chicken bile is applied in the direction of drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas. It can solve the problems of being unsuitable for patients, especially children, and poor taste, and achieves stable product quality, simple preparation, and The effect of cost reduction

Inactive Publication Date: 2008-05-14
李杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to overcome the specific fishy and bitter taste of chicken bile, overcome the problems of poor taste of existing chicken bile preparations, unsuitable oral application for patients, especially children, etc., and prepare A pharmaceutical composition of chicken bile that has no specific stench and bitter taste and does not contain sucrose and is suitable for oral use by adults, especially children. The preparations of the pharmaceutical composition are granules, capsules, tablets and dispersible tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1, chicken bile pharmaceutical composition one:

[0026] Recipe: chicken bile cream 6.5, β-cyclodextrin 84.5, xanthan gum 3, glycyrrhizinate 2, fresh creamer 2, lemon essence 2 parts.

[0027] Preparation method: crush fresh chicken gall, filter to separate chicken gall, concentrate under reduced pressure to a thick paste, then add 70-95% ethanol for reflux extraction for 3 times, the amount of ethanol is 2, 2 and 1 times that of chicken gall respectively, and the time 2, 1 and 0.5 hours respectively, after standing still, the ethanol liquid of chicken bile was filtered out, and concentrated under reduced pressure to form a thick paste. Mix β-cyclodextrin, xanthan gum, and glycyrrhizinate evenly, add it to chicken bile thick paste, mix evenly, dry under reduced pressure at 60°C, pulverize, and mix evenly with fresh milk essence and lemon essence to obtain the product.

Embodiment 2

[0028] Embodiment 2, chicken bile pharmaceutical composition two:

[0029] Prescription: chicken bile cream 39, β-hydroxypropyl cyclodextrin 52, xanthan gum 2, stevia 3, mint flavor 2, lemon flavor 2 parts.

[0030]Preparation method: Take fresh chicken gall and crush it, filter to separate the chicken gall, concentrate under reduced pressure to a thick paste, then add 70-95% ethanol for reflux extraction for 3 times, the amount of ethanol is 2, 2 and 1 times that of chicken gall respectively, and the time 2, 1 and 0.5 hours respectively. After standing still, the chicken bile ethanol liquid was filtered out, concentrated under reduced pressure to form a thick paste, dried under reduced pressure at 60° C., and pulverized to obtain chicken bile paste powder. Mix chicken bile paste powder with β-hydroxypropyl cyclodextrin, xanthan gum, stevioside, mint essence and lemon essence to obtain the product.

Embodiment 3

[0031] Embodiment 3, chicken bile pharmaceutical composition three:

[0032] Recipe: 13 parts of chicken bile paste, 78 parts of β-cyclodextrin, 3 parts of xanthan gum, 3 parts of protein sugar, 2 parts of fresh creamer, and 2 parts of chocolate essence.

[0033] Preparation method: in the chicken bile cream powder obtained by Example 2, add β-cyclodextrin, xanthan gum, protein sugar, fresh milk essence, chocolate essence, mix evenly, and obtain final product.

[0034] Change the ratio of the chicken bile paste in the prescription in Example 1, Example 2, and Example 3, change the ratio and type of the above-mentioned taste masking agent, sweetener and aroma corrective agent, and different pharmaceutical compositions can be prepared . Adopt these pharmaceutical compositions, according to common preparation technology, according to the requirement of different dosage form, add different adjuvant, can make chicken bile granule, capsule, tablet and dispersible tablet respectivel...

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PUM

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Abstract

The invention relates to a medicine composition of the chicken bile and the preparation; wherein, the preparation of the composition comprises the granule, the capsule, the tablet and the separate tablet. The invention is characterized in that: the composition comprises the chicken bile cream 3 to 43 percent, the taste masking agent 25 to 90 percent, the sweetener 0.5 to 3 percent and the aromatic correction agent 0.5 to 5.5 percent (the weight percentage). The invention has the advantages of being completely different from the technique using the inclusion method to solve the bad taste of the medicine, solving the specific stench and bitter taste of the chicken bile through the specific medicine combination way and the conventional preparation craft, being cool and tasty, fragrant and suitable taste, having no sucrose, being suitable for oral application of the adult more particularly of the child, having simple preparation and low cost, and being suitable for industrialization production.

Description

technical field [0001] The invention relates to a medical composition of chicken bile and its preparation. Background technique [0002] Chicken bile is cold in nature and bitter in taste. It has the functions of clearing heat and detoxifying, relieving cough and reducing phlegm, reducing inflammation and promoting gallbladder, nourishing yin and nourishing lungs, clearing liver and improving eyesight, etc. Chicken bile has been widely used in folks in my country to treat respiratory system, digestive system, ENT and other diseases〔 Edited by Jiangsu New Medical College. Dictionary of Traditional Chinese Medicine, Volume 1 [M]. Shanghai Science and Technology Press, Shanghai. 1985, 1199]. [0003] At present, chicken bile oral solution and pertussis tablets made from chicken bile have been listed on the market. Zhang Detong et al. first reported the preparation method of Jidan Oral Liquid [authorized publication number CN1044970C]. The total effective rate of Jidan Oral Liqu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61P11/10A61P11/14A61P1/16A61K31/575A61K35/57
Inventor 李杰
Owner 李杰
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