Mailuoning dropping pills and method for preparing the same

A technology of Ningdropping pills and Mailuo, which is applied in the field of Mailuoning dropping pills and its preparation, can solve problems such as difficult application, long processing cycle, and tediousness, and achieve the effects of simple production equipment, stable softness and hardness, and high bioavailability

Inactive Publication Date: 2012-03-28
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this process can fully extract the active ingredients, it is very cumbersome, and the ultrasonic treatment is difficult to apply in industrial production, and the macroporous adsorption resin treatment has the disadvantages of long treatment period and so on.

Method used

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  • Mailuoning dropping pills and method for preparing the same
  • Mailuoning dropping pills and method for preparing the same
  • Mailuoning dropping pills and method for preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] The preparation of embodiment 1 extract

[0077] Get 5000g Dendrobium, 5000g Scrophulariaceae, 5000g Achyranthes bidentata, and 5000g honeysuckle and grind them into coarse powder, use 70% ethanol to extract by percolation at a speed of 100ml / min, collect 12 times the percolation solution of the crude drug, recycle ethanol under low temperature and decompression, and depressurize Concentrate to an extract with a relative density of 1.20 at 50°C, centrifuge to remove insoluble impurities, add 6 times the amount of water, stir well, let stand overnight, filter, and concentrate the filtrate under reduced pressure to an extract with a relative density of 1.20 at 50°C, filter , remove the precipitate, adjust the pH value to 1-2, extract 6 times with equal volume of ethyl acetate, combine the extracts, recover the ethyl acetate, and dry under vacuum at 60°C to obtain 345g of the extract.

Embodiment 2

[0078] The preparation of embodiment 2 Mailuoning dripping pills

[0079] Take 1000g of polyethylene glycol-6000 and heat it to 60°C, add 100g of the extract in Example 1 after melting, stir evenly, move to the dropping pill machine, keep the melt temperature at 40°C, and pour 20 drops from top to bottom The dropping speed per minute is dropped into 0 ℃ paraffin at a uniform speed to make 1500 g of dropping pills.

Embodiment 3

[0080] The preparation of embodiment 3 Mailuoning dripping pills

[0081] Take 1000g of polyethylene glycol-4000 and heat it to 90°C, add 150g of the extract in Example 1 after melting, stir evenly, move to the dropping pill machine, keep the temperature of the molten liquid at 80°C, and pour 30 drops from top to bottom The dropping speed per minute is dropped into 0 ℃ paraffin at a uniform speed to make 1500 g of dropping pills.

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Abstract

The invention provides an MLN dropping pill and process for preparation. The preparation method of the medicament of the invention comprises extracting percolation dendrobium, achyranthes root, radix scrophulariae and honeysuckle flower after adding ethanol, precipitating water, purifying with ethyl acetate, and obtaining extracts, taking proper polyethylene glycol to heat, adding the extracts after melting, stirring uniformly, dropping the liquor into condensate with a proper speed, and then forming dropping pill. The dropping pill has rapid releasing speed in bodies, high bioavailability and small volume, which is carried conveniently.

Description

technical field [0001] The invention relates to a drop pill preparation prepared from a traditional Chinese medicine extract, in particular to a Mailuoning drop pill and a preparation method thereof. Background technique [0002] Mailuoning Injection is a traditional Chinese medicine compound injection developed on the basis of the famous medical prescription "Simiao Yong'an Decoction". inflammation, arteriosclerotic obliterans, cerebral thrombosis and sequelae, Takayasu arteritis, acute arterial embolism of extremities, diabetic gangrene, venous thrombosis and thrombophlebitis, etc. Chinese patent CN1557398A discloses that it also has the effect of preventing and treating angina pectoris. However, the existing preparation process of Mailuoning injection adopts water extraction and alcohol precipitation method to extract four medicinal materials simultaneously, and then extracts the active ingredient with ethyl acetate (see "Technical method of Mailuoning injection", public...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8984A61K9/20A61P9/00A61P9/10A61P9/14
Inventor 白雨郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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