Anethol trithione soft capsule and preparation method thereof

Abstract

The invention provides a soft capsule containing an anethol trithione. The soft capsule contains the anethol trithione, a substrate, a suspending agent and a surface active agent, wherein, the weight proportion of the three matters is as follows: the anethol trithione: the substrate: the suspending agent: the surface agent is equal to 1: 2 through 75: 0.1 through 10: 0.3 through 15. The substrate can be a sesame oil, a groundnut oil, a corn oil, an olive oil, a sunflower seed oil, a soybean oil, a salad oil, a cotton oil, or a colza oil or a mixture made from a plurality of these oils. The suspending agent can be a beeswax, a yellow wax, a white wax, a mixed wax, a palm oil, a hydrogenated vegetable oil, a sterin, an aluminum monostearate, a glycerin monostearate, a fatty glyceride, a fatty glyceride mixed, an aerosil, or a silicon dioxide or a mixture made from a plurality of these matters. The surface active agent is tween. The soft capsule can strengthen the beneficial effect of the anethol trithione in human body, and meanwhile shows a relativity in and out of the human body.

Description

technical field [0001] The invention provides a kind of medicine oral preparation containing anethiol and its preparation method, specifically a soft capsule containing anethione, which is further developed by utilizing the existing active ingredient anethione, and the purpose is to develop a kind of enhanced The soft capsule dosage form of the beneficial effect of trisulfide in vivo shows the correlation both in vivo and in vitro. Background technique [0002] Anethol Trthione (English name is Anethol Trthione) is an active ingredient that promotes choleresis and protects the liver. It can promote the increase of intracellular glutathione content. , increase the secretion of bile pigment, enhance the detoxification function of the liver, and is one of the ideal drugs for the treatment of gallstones, chronic hepatitis and acute and chronic cholecystitis. Due to the definite clinical curative effects of anetis trithion on liver protection, choleretic, saliva-inducing, digest...

AI Technical Summary

Problems solved by technology

Not only the peak time of the two samples is later than that of the tablet, but the peak concentration is also unusually low, and a large number of subjects cannot detect the blood drug concentration, and the individual differences of the two soft capsule samples are more extensive than those of the tablet , not statistically significant at all

[0008] This kind of experimental reality makes us more aware that if anetis trithione is used according to the usual preparation methods of soft capsules to solve the problem of poor efficacy in clinical use, it will not only fail to achieve the purpose of improvement, but even fail to achieve the minimum equivalent