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Production method of polyether carbonic acid ester with heat reversible gel

A technology of polyether carbonate and gel, which is applied in the field of water-soluble polymer synthesis and degradable medical polymer, and can solve the problem of low intrinsic viscosity, difficulty in use, transportation and storage of thermoreversible gel polyether carbonate, and difficulty in accurate Measuring and other issues, to achieve the effect of low toxicity, safe use and convenient storage

Inactive Publication Date: 2010-06-02
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The traditional preparation method of polyether carbonate with thermally reversible gel is usually solution polymerization, using the conventional coupling agent phosgene, but phosgene is a highly toxic gas, which is difficult to use, transport and store, and it is difficult to be accurate in application. Metering, the thermally reversible gel polyether carbonate prepared by using it has a small intrinsic viscosity (that is, a small molecular weight) and a single product performance

Method used

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  • Production method of polyether carbonic acid ester with heat reversible gel
  • Production method of polyether carbonic acid ester with heat reversible gel
  • Production method of polyether carbonic acid ester with heat reversible gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1. has the preparation of thermoreversible gel polyether carbonate

[0042] (1) Weigh 12.0g polyethylene glycol 6000 (PEG6000) and 4.0g polypropylene glycol 2000 (PPG2000) and join in the round-bottomed flask equipped with condenser tube, thermometer, constant pressure dropping funnel and magnetic stirring, and measure Pour 30mL of dichloromethane into it, seal it, and stir it magnetically to dissolve the solid completely. An anhydrous calcium chloride drying tube is attached to the condensation tube.

[0043] (2) Pipette 2.9 mL of pyridine into the above mixture, stir and place in an ice-water bath.

[0044] (3) Weigh 1.78 g of solid phosgene and dissolve it in 10 mL of dichloromethane to make the concentration of solid phosgene 0.6 mol / L, then quickly pour it into the dropping funnel. In an ice-water bath, the solid phosgene solution was slowly added dropwise to the above mixture, stirring rapidly while dropping, and the dropwise addition was completed aft...

Embodiment 2

[0048] Embodiment 2. As described in Example 1, the difference is that polyethylene glycol 4000 is used instead, and 8.0g is dropped into to obtain 9.8g of a viscous solid product with thermoreversible gel polyether carbonate, and the productive rate is 71.8%. The weight average molecular weight is 7.56×10 4 g / mol.

Embodiment 3

[0049] Embodiment 3. As described in Example 1, the difference is that polyethylene glycol 10000 is used instead, and 20.0g is dropped into to obtain 20.2g of a viscous solid product with thermoreversible gel polyether carbonate, and the productive rate is 78.4%. The weight average molecular weight is 6.82×10 4 g / mol.

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Abstract

The invention relates to a method which utilizes solid phosgene for preparing thermal reversible gel polyether carbonate, belonging to water-soluble macromolecule synthesizing field and degradable medical technical field. Using the solid phosgene as a coupling agent, hydrophilic monomer polyethylene glycol (PEG) and hydrophobic monomer polypropylene glycol (PPG) are polymerized in the solution with pyridine as a catalyzer. The polymerization can be smoothly progressed at the temperature a little higher than chamber temperature to obtain macromolecule thermal reversible gel polyether carbonatewhich is precipitated by the mixed solution of anhydrous methyl alcohol and anhydrous ether and then dried to obtain glutinous solid products. The polymer has good water-solubility and prominent reversible gel effect, thus having wide application prospect in drug delivery, tissue project and contact lenses fields, etc.

Description

technical field [0001] The invention relates to a method for preparing thermally reversible gel polyether carbonate by using solid phosgene, and belongs to the technical field of water-soluble polymer synthesis and degradable medical polymer. Background technique [0002] Polyether carbonate with thermoreversible gel is a kind of polymer widely used in the field of bioengineering. Aqueous solutions of such substances have a characteristic: they have a lower critical solution temperature (LCST), and they have a low viscosity at room temperature. After heating up, the viscosity increases sharply in a small temperature range. coagulated to produce a semi-solid gel. This feature is very important for the application of drug release systems. It can be injected or implanted in the form of a solution at room temperature, and transformed into a gel at body temperature to become a drug release matrix to play a slow-release and controlled-release role. . Because of its simple prepa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G64/20C08G64/22A61K47/34
Inventor 谭业邦王月霞
Owner SHANDONG UNIV