Coenzyme Q10 injection
An injection and coenzyme technology, applied in the field of medicine, can solve problems such as the decrease of turbid precipitate content, and achieve the effects of low histamine release, low toxicity and side effects, and high physiological tolerance
An injection and coenzyme technology, applied in the field of medicine, can solve problems such as the decrease of turbid precipitate content, and achieve the effects of low histamine release, low toxicity and side effects, and high physiological tolerance
CN101278907BInactive Publication Date: 2011-03-02郑微
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Embodiment 1
[0034] Example 1: Coenzyme Q10 5g, Solutol HS 15 60g, glycerol 10g, thiourea 15g, adjust the pH value to 4.5, and dilute to 5L with water for injection.
Embodiment 2
[0035] Example 2: Coenzyme Q10 5g, Solutol HS 15 10g, ethanol 20g, sodium metabisulfite 5g, adjust the pH value to 2.0, and dilute to 1L with water for injection.
Embodiment 3
[0036] Example 3: Coenzyme Q10 5g, Solutol HS 15 25g, polysorbate 80 50g, propylene glycol 20g, sodium bisulfite 2.5g, adjust the pH value to 4.0, and dilute to 5L with water for injection.
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The invention discloses the novel combined coenzyme Q10 parenteral solution, mainly containing the coenzyme Q10 as active component, polyethylene glycol 15-hydroxyl stearate as solubilizing agent and water for injection as solvent. One or more solvents of cosolvent, acidity regulator, osmoregulator and stabilizing agents can be also added. Low hemolyzation, extreme low histamine release and higher physiological tolerance of a novel solubilizing agent Solutol HS 15 adopted by the parenteral solution remarkably improves clinical medication security and the compliance of a patient; and the parenteral solution has the advantages of good stability, longer period of validity, higher medication convenience for a clinician, better storage and stable transportation, higher security for the clinical medication and better compliance of the patient. The parenteral solution also has the advantages of simple preparation technology, simple and convenient quality control and lower production cost, thereby being beneficial to industrialization production.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to a coenzyme Q10 injection solubilized by a novel surfactant. Background technique [0002] Coenzyme Q10, also known as decenoquinone, also known as ubiquinone Q10 and ubiquinone-50, is a fat-soluble quinone compound and one of the important members of coenzyme Q. It has the common characteristics of vitamins and its chemical structure is similar to vitamin K. Coenzyme Q10 is widely found in the cells of plants and microorganisms, as well as in the hearts, livers, spleens and kidneys of animals. Coenzyme Q10 is a good biological drug, which has various biological functions, has the advantages of small dose, low toxicity, and can assist in the treatment of various diseases, and has been widely used in clinical practice. Coenzyme Q10 has the functions of natural anti-oxidation and activation of cell metabolism, which can significantly improve human immunity. Clinically, it is main...
Claims
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Patent Timeline
02 Mar 2011
Publication
CN101278907B
- IPC
- A61K9/08; A61K31/122; A61K47/34; A61P39/06; A61K47/10; A61K47/14; A61K47/26
- Inventors
- 姚定全; 刘红